The play of chance

When treatments are compared, any differences in outcome events may simply reflect the play of chance. Increasing the number of events studied in research reduces the likelihood of being misled by the play of chance.


JLL Essay
3.0 Taking account of the play of chance

Taking account of the play of chance

 

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A statistical note on the analysis of the 1948 MRC streptomycin trial. JLL Bulletin: Commentaries on the history of treatment evaluation.

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Held L, Matthews RAJ (2022).
Paradigm lost: Carl Liebermeister and the development of modern medical statistics. JLL Bulletin: Commentaries on the history of treatment evaluation.

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Big Data, Big Bias? Evidence on the effects of selection bias in large observational studies

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