Factorial design

A comparison of two or more factors in a randomized trial.


JLL Essay
2.2 The need to compare like-with-like in treatment comparisons

Comparing like with like

 

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Wilson C, Pollock MR, Harris AD (1945)
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Wilson C, Pollock MR, Harris AD (1946)
Diet in the treatment of infective hepatitis. Lancet 1:881-883.

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Doll R, Pygott F (1952)
Factors influencing the rate of healing of gastric ulcers: admission to hospital, phenobarbitone, and ascorbic acid. Lancet 1: 171-175.

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Chalmers TC, Eckhardt RD, Reynolds WE, Cigarroa JG, Deane N, Reifenstein RW, Smith CW, Davidson CS (1955)
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Franz WL, Sands GW, Heyl HL (1956)
Blood ascorbic acid level in bioflavinoid and ascorbic acid therapy of common cold. JAMA 162:1224-1226.

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Tebrock HE, Arminio JJ, Johnston JH (1956)
Usefulness of bioflavinoids and ascorbic acid in treatment of common cold. JAMA 162:1227-1233.

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Peto R (1978)
Clinical trial methodology. Biomedicine 28 (special issue):24-36.

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Davidson I, Hillier VF (2002)
Comparison of four methods of allocation for clinical trials with small sample sizes. Physiotherapy 88;12:722-729, ISSN 0031-9406.

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Pollock JI (2005).
Two controlled trials of supplementary feeding of British school children in the 1920s. JLL Bulletin: Commentaries on the history of treatment evaluation.

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Pollock JI (2017).
A controlled trial using a factorial design reported in 1946. JLL Bulletin: Commentaries on the history of treatment evaluation.

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Glasziou PP, Tikkinen KAO (2021).
The RECOVERY trial platform: a milestone in the development and execution of treatment evaluation during an epidemic. JLL Bulletin: Commentaries on the history of treatment evaluation.

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Glasziou P, Matthews R, Boutron I, Chalmers I, Armitage P† (2023)
The differences and overlaps between ‘explanatory’ and ‘pragmatic’ controlled trials: a historical perspective. JLL Bulletin: Commentaries on the history of treatment evaluation.

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