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Acknowledgements
The editors are grateful to:
Elsevier Ltd. for making a pdf of this article available (letter to Iain Chalmers from Laura Pritchard, 14 May 2014). For conditions of further reproduction, see here.
Key articles
- Campbell MJ (2012).
Doing clinical trials large enough to achieve adequate reductions in uncertainties about treatment effects. - Armitage P (2013).
The evolution of ways of deciding when clinical trials should stop recruiting.