Gruppo Italiano per lo Studio della Streptochinasi nell’Infarto Miocardico (GISSI) (1986)

Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1: 397-402.
In the mid-1980s, through widespread collaboration, the Italian Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI) published  the first report of a ‘mega-trial’ of a treatment. This , confirmed  the beneficial effects of thrombolysis after heart attack.

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Acknowledgements

The editors are grateful to:

Elsevier Ltd. for making a pdf of this article available  (letter to Iain Chalmers from Laura Pritchard, 14 May 2014). For conditions of further reproduction, see here.

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