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James Lind LibraryThe James Lind Library
Illustrating the development of fair tests of treatments in health care

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Sinclair JC, Bracken MB (1992)

Effective care of the newborn infant. Oxford: Oxford University Press.

Title page(s)

Sinclair_Bracken_1992-tp1 Sinclair_Bracken_1992_tp2

 

Key passage(s)

Sinclair_Bracken_1992-kp1 Sinclair_Bracken_1992_kp2 Sinclair_Bracken_1992_kp3 Sinclair_Bracken_1992_kp4 Sinclair_Bracken_1992_kp5

RELEVANT TOPICS

  • Biases in systematic reviews
  • Using meta-analysis
  • Preparing and maintaining systematic reviews
  • Using the results of research

Key articles

  • Fox DM (2011).
    Systematic reviews and health policy: the influence of a project on perinatal care since 1988.
  • Clarke M (2015).
    History of evidence synthesis to assess treatment effects: personal reflections on something that is very much alive.
  • Glasziou P, Aronson JK (2017).
    A brief history of clinical evidence updates and bibliographic databases.

All topics

  • Individual patient data
  • Pre-clinical
  • Fair tests of treatments
    • The need to address treatment uncertainties
      • Principles of Testing
    • Treatment comparisons are essential
      • Dramatic effects
      • Placebo effects
    • Treatment comparisons must be fair
  • Biases
    • Design bias
    • Allocation bias
      • N-of-1 crossover
      • Cluster allocation
      • Crossover tests
      • Factorial design
    • Co-intervention bias
    • Observer bias
      • Double dummy
    • Analysis bias
    • Biases in judging unanticipated possible effects
    • Reporting bias
    • Biases in systematic reviews
    • Researcher/sponsor bias and fraud
  • The play of chance
    • Recording and interpreting numbers
    • Quantifying uncertainty
    • Using meta-analysis
  • Bringing it all together for the benefit of patients and the public
    • Improving reports of research
    • Preparing and maintaining systematic reviews
    • Using the results of research

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