Nettleton T (1722)
Part of a letter from Dr. Nettleton, physician at Halifax, to Dr. Jurin, R. S. Sec concerning the inoculation of the small pox, and the mortality of that distemper in the natural way. Philosophical Transactions of the Royal Society of London (1722-1723) 32:209-212.
Early in the 18th century, Thomas Nettleton, a physician in Halifax, England, compiled figures to compare the death rate from natural smallpox with that following inoculation.
- Boylston AW (2010).
Thomas Nettleton and the dawn of quantitative assessments of the effects of medical interventions.
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James Jurin and the avoidance of bias in collecting and assessing evidence on the effects of variolation.
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Quantitative evidence for judgments on the efficacy of inoculation for the prevention of smallpox: England and New England in the 1700s.
- Huth EJ (2006).
Benjamin Franklin’s (1706-1790) place in the history of medicine.
- Boylston AW (2008).
William Watson’s use of controlled clinical experiments in 1768.
- Boylston AW, Williams AE (2008).
Zabdiel Boylston’s evaluation of inoculation against smallpox.
- Morabia A (2010).
Edward Jenner’s 1798 report of challenge experiments demonstrating the protective effects of cowpox against smallpox.
- Tröhler U (2010).
The introduction of numerical methods to assess the effects of medical interventions during the 18th century: a brief history.