Jefferson T, Jones MA, Doshi P, Del Mar CB, Hama R, Thompson MJ, Spencer EA, Onakpoya I, Mahtani KR, Nunan D, Howick J, Heneghan CJ (2014).

Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database of Systematic Reviews 2014, Issue 4. Art. No.: CD008965. DOI:10.1002/14651858.CD008965.pub4.
In 2014, in a major methodological development, Tom Jefferson and his colleagues conducted a systematic review of 46 trials of anti-flu drugs, drawing on information reported in more than 160,000 pages of Clinical Study Reports prepared for drug regulatory authorities.

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Full set of peer review & editorial comments going back to A047 and A46:

The predecessor reviews to A159 are available here:
All the clinical study reports used in the A159 review are available here:
A brief explanation of the background:

Additional material made available in May 2016:

Neuraminidase inhibitors for influenza: a systematic review and meta-analysis of regulatory and mortality data” has now been published in the HTA journal on the NIHR Journals Library website and can be downloaded here:

See also the timeline of the story since publication of the original Cochrane review in 2014:

See correspondence up to 2014 on

See also BMJ coverage:

Debate on whether Tamiflu prevents flu deaths reignites after new analysis:

BMJ 2016; 353 doi: (Published 01 June 2016) Cite this as: BMJ 2016;353:i3077