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During the late 1930s, Pearl Kendrick and Grace Eldering, working in the Michigan Department of Health, did an important controlled study to evaluate the effects of the whooping cough vaccine they had developed.
Marks HM (2006).
The Kendrick-Eldering-(Frost) pertussis vaccine field trial.
Other articles
Jefferson T (2006).
Why the MRC randomized trials of whooping cough (pertussis) vaccines remain important more than half a century after they were done.
Chalmers I (2010).
Joseph Asbury Bell and the birth of randomized trials.