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James Lind Library
Illustrating the development of fair tests of treatments in health care
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Ben Cao Tu Jing (11th century)
Atlas of Materia Medica. Song Dynasty (960-1279).
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Stuart, James, King of Great Britaine, France and Ireland (1616)
A counterblaste to tobacco. In: The workes of the most high and mightie prince, James Published by James, Bishop of Winton, and Deane of his Majesties Chappel Royall. London: printed by Robert Barker and John Bill, printers to the Kings most excellent Majestie, pp 214-222.
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de Fontaney F (1703)
Letter to F de la Chaise, from Cheu-Chan (a port in the Province of ‘Chekian’), dated 15 February. In: Lettres Édifiantes Et Curieuses, Écrites Des Missions Étrangères Par Quelques Missionnaires De La Compagnie De Jesus [Edifying and curious letters, written from the foreign missions by some missionaries of the Company of Jesus]. 34 vols. Paris: Chez Nicolas le Clerc, rue Saint Jacques, à l’Image Saint Lambert, 1703-1776. Vol. 7 (1707): pp. 234-244.
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Berkeley G (1752)
Farther thoughts on tar-water. In: Bishop of Cloyne. A miscellany, containing several tracts on various subjects. London: Tonson and Draper.
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Repertoire du Regi[s]tre CC (1761)
Maladies Vénériennes, et la Chambre Noble [Venereal diseases, and the City Council]. Archives d’Etat de Genève, Arch. Hosp. Aa 104, 18 janvier, p 53, and 6 décembre, pp 135-6.
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Lind J (1763)
Two papers on fevers and infection. London: D Wilson.
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Stone E (1764)
An account of the success of the bark of the willow in the cure of agues. Philosophical Transactions 53:195-200.
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Lind J (1771)
An essay on diseases incidental to Europeans in hot climates. London: Becket and De Hondt.
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Society of Gentlemen in Scotland (1771)
Medicine. Encyclopaedia Britannica. Vol 1. Edinburgh: Bell & Macfarquhar, pp 630-632.
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Gregory J (1772)
Lectures on the duties and qualifications of a physician. London: Strahan and Cadell. (new ed.) Edinburgh: Creech.
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Sims J (1774)
A discourse on the best methods of prosecuting medical enquiries. London: J Johnson, p78-9, 80, 86-88, 99-101.
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Millar J (1777)
Observations on the practice in the medical department of the Westminster General Dispensary. London, by order of the Governors.
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Dobson M (1779)
A medical commentary on fixed air. Chester: J. Monk.
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Millar J (1779)
Observations on the management of the prevailing diseases particularly in the Army and Navy. London, for the author.
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Home F (1780)
Clinical experiments, histories and dissections. Edinburgh: Creech; London: Murray.
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McCausland R (1783)
Facts and observations on different medical subjects. Medical Commentaries viii (1781/82), 247-96.
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Fowler T (1785)
Medical reports of the effects of tobacco in the cure of dropsies and dysuries.... London: J Johnson.
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Withering W (1785)
An account of the foxglove and some of its medical uses: with practical remarks on dropsy and other diseases. London: J and J Robinson.
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Fowler T (1786)
Medical reports of the effects of arsenic in the cure of agues, remitting fevers and periodic headachs. London: J Johnson, pp 105-107.
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Parry CH (1786)
Experiments relative to the medical effects of Turkey Rhubarb, and of the English Rhubarbs, No. I and No. II made on patients of the Pauper Charity. Letters and Papers of the Bath Society 11:431-453.
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Hunter J (1788)
A treatise on the venereal disease. London: G Nicol and J Johnson, pp 69-70.
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Black W (1789)
An arithmetical and medical analysis of the diseases and mortality of the human species. London: J Johnson.
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Robertson R (1789)
Observations on jail, hospital, or ship fever. New ed. London: for the Author.
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Robertson R (1790)
Essay on fever. London: printed for the author.
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Sims RC (1791)
Letter VI. Letters and Papers of the Bath Society III: 486-487.
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Clark J (1792)
Observations on the diseases which prevail in long voyages to hot countries. London: J Murray.
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Ferriar J (1792)
Medical histories and reflections. Vol 1. London: Cadell and Davies.
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Fordyce G (1793)
An attempt to improve the evidence of medicine. Transactions of a Society for the Improvement of Medical and Chirurgical Knowledge. London: J Johnson.
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Rowley W (1793)
The causes of a great number of deaths amongst adults and children. 2nd edn. London: Newbery.
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Ferriar J (1795)
Medical histories and reflections. Vol. 2. London: Cadell and Davies.
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Millar J (1798)
Observations on the management of diseases in the Army and Navy in reply to Dr. Monroe. London: for the Author.
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Rollo J (1801)
A short account of the Royal Artillery Hospital at Woolwich. London: Mawman.
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Fordyce G (1802)
A second dissertation on fever. London: J Johnson.
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Haygarth J (1805)
A clinical history of diseases 1. Acute rheumatism. 2. Nodosity of the joints. London: Cadell and Davies.
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Sutton T (1806)
A practical account of remittent fever. London: Robinson, p 16-17.
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Warren J (1812)
Remarks on Angina Pectoris. New England Journal Medicine & Surgery 1:1-11.
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Blane G (1813)
Observations on the comparative prevalence, mortality, & treatment of different diseases.... Medico-chirurgical Transactions, Vol 4, p 89-141, London.
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MacGrigor J (1816)
Sketch of the medical history of the British armies in the peninsula of Spain and Portugal, during the late campaigns. Medico-chirurgical Transactions 6:381-489.
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MacLean C (1818)
Results of an Investigation, respecting Epidemic and Pestilential Diseases. Vol. 2. London: Underwood.
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Double FJ (1820)
Considérations thérapeutiques sur une nouvelle préparation de quinquina. Revue médicale, 6ème livraison.
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Elliotson J (1823)
Medical properties of quinine. Medico-Chirurgical Transactions 12:543-564.
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Magendie F (1829)
Formulaire pour la préparation et l'emploi de plusieurs médicaments. Paris, imprimerie de Plassan,1ère édition.
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Bigelow J (1835)
A discourse on self-limited diseases, delivered before the Massachusetts Medical Society at their annual meeting, May 27, 1835. Boston: Nathan Hale p 8-10.
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Forbes J (1846)
Homoeopathy, allopathy and “young physic”. British and Foreign Medical Review 225-265.
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Thomson TRH (1846)
On the value of quinine in African remittent fever. Lancet 47:244-245.
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Bryson A (1847)
Report on the Climate and Principal Diseases of the African Station. London: Printed by order of the Lords Commissioners of the Admiralty.
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Balfour TG (1854)
Quoted in West C. Lectures on the Diseases of Infancy and Childhood. London, Longman, Brown, Green and Longmans, p 600.
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Bryson A (1854)
On the prophylactic influence of quinine. Medical Times and Gazette 8:6-7.
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Treatment Committee of the Medical Council (1855)
Report on the results of the different methods of treatment pursued in epidemic cholera. [Metropolitan Report and Report on the Provinces throughout England and Scotland]. Report to the General Board of Health. London: Her Majesty’s Stationery Office.
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McShane C (1856)
Medical Statistical Returns of the African Station. In: Statistical Report of the Health of the Royal Navy for the year 1856. London: House of Commons, pp 82-83.
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Baikie WB (1856)
Narrative of an exploring voyage up the rivers Kwora and Binue in 1854. London: John Murray.
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Thompson T (1859)
Observations on the administration of ozonized oils. Medical and Chirurgical Transactions 42:349-360.
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Holmes OW (1861)
Currents and countercurrents in medical science with other addresses and essays. Boston: Ticknor and Fields, 1861.
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Béclard PA (1863)
Rapport général sur les prix décernés en 1862 [General report on the prizes awarded in 1862]. Mémoires de l’Académie Impériale de Médecine XXVI, Paris: Ballière, pp. xxii-xxxv.
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Barclay AW (1864)
Medical errors: fallacies connected with the application of the inductive method of reasoning to the science of medicine. London: Churchill, p 55 and 71-73.
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Liebreich O (1869)
Das Chloral, ein neues Hypnoticum und Anaesthetikum [Chloral, a new hypnotic and anaesthetic]. Berliner Klinische Wochenschrift 6:325-327.
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Crichton Browne J (1872)
Conium in the treatment of acute mania. Lancet 1:217-8.
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Maclagan T (1876)
The treatment of acute rheumatism by salicin. Lancet 1:383-84.
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Hartridge G (1886)
Tobacco amblyopia. BMJ 1:200.
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Fry HD (1887)
The value of the antiseptic method in obstetric practice and its application to the forceps operation. JAMA 8:388-390.
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Boxall, cited in Williams J (1888)
On the effect of ergot on the involution of the uterus. BMJ 1:229.
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Stuart W (1889)
A remarkable case of morphine addiction. BMJ 1:1051-52.
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Phillips J (1890)
On the analgesic value of antipyrin intra - and post - partum. Lancet 2:605-607.
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Andrew J (1891)
Harveian Oration. London: Adlard and Son. p 16-19.
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Dymock W, Warden CJH, Hooper D (1891)
A history of the principal drugs of vegetable origin met with in British India. Pharmacographia Indica Vol. II. London: Kegan Paul, Trench, Trübner, pp 180-181.
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Priestley J (1895)
On the value of eucalyptus oil as a disinfectant in scarlet fever. Lancet 1:861-863.
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Heiberg P (1897)
Studier over den statistiske undersøgelsesmetode som hjælpemiddel ved terapeutiske undersøgelser [Studies on the statistical study design as an aid in therapeutic trials]. Bibliotek for Læger 89:1-40.
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Anonymous (1899)
Echoes and news: the chlorine treatment of diphtheria. Medical News 74:403.
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Williams FH (1899)
Scarlatina. Reports of societies. Boston Medical And Surgical Journal 141:348.
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Koch R (1900)
Vierter Bericht über die Thätigkeit der Malaria-Expedition, die Monate März und April 1900 umfassend [Fourth report on the activity of the Malaria Expedition, comprising the months of March and April 1900] Deutsche medicinische Wochenschrift 25:397-398.
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Waters EE (1903)
Malaria as seen in the Andamans penal settlement. Lancet 1:1657-62.
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Celli A (1903)
La malaria in Italia durante il 1902. Parte II: Profilassi della malaria. [Malaria in Italy in 1902. Part II: Prophylaxis of Malaria]. Annali di Igiene Sperimentale 13:322-343.
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Cousin M (1905)
Des éruptions consecutives aux injections de sérum antidiphthérique et de leur traitement prophylactique par l’ingestion de clorure de calcium. Thèse pour le Doctorat en médicine. Paris : Jules Rousset, 36-44.
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Cushny AR, Peebles AR (1905)
The action of optical isomers. II. Hyoscines. J Physiology 32:501-510.
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Netter A (1906)
Efficacité de l’ingestion de chlorure de calcium comme moyen préventif des éruptions consecutives aux injections de sérum [Effect of the ingestion of calcium chloride for preventing eruptions following serum injections]. Séances et Mémoires de la Société de Biologie 58:279-280.
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Drake DJ (1907)
The treatment of dysentery by yellow santonine. Journal of Tropical Medicine and Hygiene 10:351-352.
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Gewin J (1908)
Chlorkalzium gegen die Serumkrankheit [Calcium chloride against serum sickness]. Muenchener Medizinische Wochenshcrift 50:2670-2671.
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Rivers WHR (1908)
The influence of alcohol and other drugs on fatigue. London: Edward Arnold.
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Anonymous (1908)
Alcohol in the treatment of pneumonia and enteric fever. Lancet 157:442.
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Alt K (1909)
Behandlungsversuche mit Arsenophenylglyzin bei Paralytikern [Treatment experiments with arsenophenylglycine in paralytics]. Muenchener Medizinische Wochenschrift 56:1457-1459.
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Döderlein D (1910)
The origin and prevention of puerperal fever. BMJ 2:1222-24.
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Wechselmann W (1910)
Über die Behandlung der Syphilis mit Dioxydiamido-arseno-benzol [On the treatment of syphilis with dioxy-diamido-arseno-benzol]. Berliner Klinische Wochenschrift 47:1261-1264.
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Hollingworth HL (1911)
The influence of caffeine on mental and motor efficiency. Archives of Psychology/Columbia Contributions to Philosophy and Psychology 20:iii-v
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Solis-Cohen M, Strickler A (1911)
The effect produced by some therapeutic measures on the different forms of leucocytes in pulmonary tuberculosis. New England Journal of Medicine 165:563-568.
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McDonagh JER (1912)
Salvarsan in syphilis and allied diseases. Oxford: Oxford Medical Publications.
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Hewlett AW (1913)
Clinical effects of “natural” and “synthetic” sodium salicylate. JAMA 61:319-321.
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Council on Pharmacy and Chemistry (1913)
Sinkina. JAMA 61:1056-1058.
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Carver AE (1914)
Pneumosan in the treatment of pulmonary tuberculosis. Lancet 2:372-373.
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Baer JL (1915)
Scopolamin-morphin treatment in labor. JAMA 64:1723-1728.
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Bastedo WA (1915)
Clinical Experience with Liquid Paraffin (Liquid Petrolatum): A Comparative Investigation Made Under the Auspices of the Council on Pharmacy and Chemistry. JAMA 64: 808-809.
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Plass ED (1916)
Post partum care of perineum. Bulletin of Johns Hopkins Hospital 27:107-109.
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Council on Pharmacy and Chemistry (1917)
Biniodol. JAMA 68: 650-51.
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Avata AA, Woodyatt RT (1918)
Treatment of facial erysipelas at Camp Cody, N.M. JAMA 71:900-01.
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Bleuler E (1919)
Das Autistisch-Undisziplinierte Denken in der Medizin und Seine Überwindung [Autistic-undisciplined thinking in medicine and how to overcome it]. Berlin: Springer.
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Leighton Kesteven H (1919)
A study of epidemic influenza in Australia. Lancet 2:1189-91.
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Marine D, Kimball OP (1920)
The prevention of simple goiter in man: fourth paper. Archives of Internal Medicine 25:661-72.
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Acton HW (1920)
Researches on the treatment of benign tertian fever. Lancet 1:1257-1261.
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Diehl HS (1925)
Value of Chlorin in the treatment of colds. JAMA 84:1629-32.
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Fletcher W (1925)
The relative efficiency of quinine and quinidine in the treatment of malaria. In: Medical Research Council. Clinical comparisons of quinine and quinidine. London: Her Majesty's Stationery Office, pp 17-27.
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Malaria Commission of the Health Organisation (1925)
Report on its tour of investigation in certain European countries in 1924. Geneva: League of Nations. C.H. 273.
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Moir JC (1925)
Comparison of the narcotic effects of the two hyoscines (scopolomaines). BMJ 2:514-515.
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Medical Research Council (1925)
Report of the committee upon cinchona derivatives and malaria. In: Clinical comparisons of quinine and quinidine. London: HMSO, pp 5-16.
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Swellengrebel NH (1925)
A summary of the more important facts on adult anophelines and their larvae observed by us or brought to our notice duing our tour through eastern Europe and Italy (May-September 1924). pp183-190. In: Malaria Commission of the Health Organisation (1925). Report on its tour of investigation in certain European countries in 1924. Geneva: League of Nations. C.H. 273.
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Maier HW (1926)
L’ergotamine, inhibiteur du sympathique étudié en clinique, comme moyen d’exploration et comme agent thérapeutique. Revue Neurologique. 1:1104 (June).
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Mauel W (1926)
Ist das Omnadin bei kruppöser Pneumonie wirksam [Is Omnadin effective in pneumonia with croup]? Münchener Medizinische Wochenschrift 73:652.
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Sinton JA (1926)
Studies in Malaria, with special reference to Treatment. Part I. Introduction and routine methods. Indian Journal of Medical Research 13: 565-577.
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Sinton JA (1926)
Studies in Malaria, with special reference to treatment. Part II. The effects of treatment on the prevention of relapse in infections with Plasmodium Falciparum. Indian Journal of Medical Research 13: 579-601.
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Harris KE (1927)
Series of cases of auricular fibrillation treated with quinidine sulphate. Heart 14:283-288.
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Sinton JA (1927)
Studies in Malaria, with special reference to treatment. Part VII. The intravenous injection of sodium stovarsol in the treatment of benign tertian malaria. Indian Journal of Medical Research 15:287-299.
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Earp JR (1927)
The need for reporting negative results. JAMA 88:119.
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Freeman J (1929)
Discussion on the action and use of ephedrine. Proceeding of Royal Society of Medicine 22:1369.
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Pearce RM (1929)
The treatment of influenza with S.U.P. 36. BMJ 2:663-666.
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Sinton JA, Bird W (1929)
Studies in Malaria, with special reference to treatment. Part XI: The Cinchona alkaloids in the treatment of benign tertian malaria. Indian Journal of Medical Research 16: 725-746.
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Kauders O (1930)
Ueber Nachbehandlung nach Malariatherapie [On the management of patients after malaria therapy]. Deutsche Medizinishe Wochenshcrift 61:400-401.
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Lewis T (1930)
Angina pectoris associated with high blood pressure and its relief by amyl nitrate. Heart 14:305-327.
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Wyckoff J, DeGraaf AC, Parent S (1930)
Influence of salicylates on the heart in rheumatic fever. American Heart Journal 5:568-573.
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Wyckoff J, Du Bois EF, Woodruff IO (1930)
The therapeutic value of digitalis in pneumonia. JAMA 95:1243-1249.
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Amberson JB, McMahon BT, Pinner M (1931)
A clinical trial of sanocrysin in pulmonary tuberculosis. American Review of Tuberculosis 24:401-435.
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Davis WE (1931)
The incidence of untoward symptoms following the intravenous injection of sodium tetraiodophenolphthalein in cholecystography. New England Journal of Medicine 205:534-6.
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Friend GE (1931)
Amidopyrin in measles. BMJ 1:33.
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Manson-Bahr P (1931)
Modern methods of treatment of intestinal amœbiasis. Proceedings of Royal Society of Medicine 24:1538–1548.
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Roos H (1931)
Behandling av kruppös pneumoni med kininjektioner [Treatment of acute pneumonia with quinine injections]. Finska Läkaresällskapets Handlingar 73:778-789.
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King D (1931)
Prevention of post-operative pulmonary complications. Report and Notices of Meetings. The New England Journal of Medicine 205:1320.
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Sanders JP, Dawson, WT (1932)
Efficacy of quinidine in malaria. JAMA 99:1773-7.
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Borovsky MP, Steigmann F (1933)
Amidopyrine in the treatment of measles. JAMA 100:1859-61.
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Diehl HS (1933)
Medicinal treatment of the common cold. JAMA 101:2042-2049.
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Evans W, Hoyle C (1933)
The comparative value of drugs used in the continuous treatment of angina pectoris. Quarterly Journal of Medicine 7:311-338.
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Bray GW, Witts LJ (1934)
Pseudo-ephedrine in asthma. Lancet 1:788-90.
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Evans W, Hoyle C (1934)
The prevention and treatment of individual attacks of angina pectoris (angina of effort). Quarterly Journal of Medicine 3:105-135.
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Walker MB (1934)
Treatment of myasthenia gravis with physostigmine. Lancet 1:1200-1201.
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Hediger E, Gold H (1935)
USP ether from large drums and ether from small cans labeled ‘For Anesthesia’. JAMA 104:2244-2448.
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Lennox WG, Von Storch TJC (1935)
Experiences with ergotamine tartrate in 120 patients with migraine. JAMA 105:169-171.
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Robin L, Van-Huan T (1935)
Essais comparés de prophylaxie médicamenteuse en région hyperendémique par la praequine et la quinine ou la quinacrine [Comparative trials of anti-malarial drug prophylaxis in a hyperendemic area with præquine, associated with quinine or quinacrine]. Bulletin de la Société de Pathologie exotique 28:650-658.
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Hicks EP, Diwan Chand S (1935)
The relative clinical efficacy of totaquina and quinine. In: Records of the Malaria Survey of India 5:39-50.
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Colebrook L, Kenny M (1936)
Treatment of human puerperal infections, and of experimental infections in mice, with prontosil. Lancet 1:1279-1286.
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Colebrook L, Kenny M (1936)
Treatment with prontosil of puerperal infections due to haemolytic streptococci. Lancet 2:1319-1322.
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Curphey TJ, Solomon S (1936)
The therapeutic value of calcium salts in serum sickness. New England Journal of Medicine 214:150-153.
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Moir JC (1936)
Clinical experiences with the new alkaloid, ergometrine. BMJ 2:799-801.
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O’Sullivan ME (1936)
Termination of 1000 attacks of migraine with ergotamine tartrate. JAMA 107:1208-1212.
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Sutliff WD (1936)
Adequate tests of curative therapy in man. Annals of Internal Medicine 1936-1937;10:89-97.
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Bastianelli G, Mosna E, Canalis A (1937)
Prevention and treatment of malaria by synthetic drugs. Bulletin of the Health Organisation of the League of Nations 6:822-891.
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Colebrook L, Purdie AW (1937)
Treatment of 106 cases of puerperal fever by sulphanilamide. Lancet 2:1237-1242 & 1291-1294.
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Field JW, Niven JC, Hodgkin EP (1937)
The prevention of malaria in the field by the use of quinine and atebrine. Bulletin of the Health Organisation of the League of Nations 6:236-290.
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Gold H, Kwit NT, Otto H (1937)
The xanthines (theobromine and aminophyllin) in the treatment of cardiac pain. JAMA 108;2173-2179.
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Hesseltine HC (1937)
Evaluation by controlled series of vaginal trichomoniasis therapies. JAMA 109:768-71.
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Hogarth JC (1937)
Para-benzylaminobenzene-sulphonamide in the treatment of scarlet fever. BMJ 2:1160-1162.
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Parrot A, Catanei A, Ambialet R, Clastrier J (1937)
Comparative experiments in mass prophylaxis of malaria by means of quinine and synthetic drugs (quinacrine and praequine). Bulletin of the Health Organization of the League of Nations 6:685-765.
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Peters BA, Cullum IM (1937)
Post-scarlatinal nephritis: a study in prevention. BMJ 1:1020-21.
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Peters BA, Havard RV (1937)
Chemotherapy of streptococcal infections with p-bezylamino-benzene-sulphonamide. Lancet 1:1273-4.
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Snodgrass WR, Anderson T (1937)
Prontosil in the treatment of erysipelas: a controlled series of 312 cases. BMJ 2:101-104.
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Snodgrass WR, Anderson T (1937)
Sulphanilamide in the treatment of erysipelas: a controlled series of 270 cases. BMJ 2:1156-9.
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Wilbur DL, MacLean AR, Allen EV (1937)
Clinical observations on the effect of Benzedrine sulphate. JAMA 109:549-54.
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Malaria Commission (1937)
The treatment of Malaria: Study of synthetic drugs, as compared with Quinine, in the therapeutics and prophylaxis of Malaria. Bulletin of the Health Organisation, Vol VI, no. 6.
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Riseman JEF, Brown MG (1937)
Medicinal treatment of angina pectoris. Archives of Internal Medicine 60:100-118.
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Bahnsen P, Jacobsen E, Thesleff H (1938)
Studien über die Wirkung von beta-phenyl-isopropylaminsulfdat (Mecodrin) auf normale Menschen. [Studies on the effect of beta-phenyl-isopropylaminsulfdat (Mecodrin) on normal volunteers]. Klinische Wochenschrift 17:1074-1078.
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Evans GM, Gaisford WF (1938)
Treatment of pneumonia with 2-(p-aminobenzene sulphonamido) pyridine. Lancet 2:14-19.
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Gaudin HJ, Zide HA, Thompson GJ (1938)
Use of sulfanilamide after transurethral prostatectomy. JAMA 110:1887-90.
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Johnstone RW (1938)
Prophylactic use of sulphonamide preparations in obstetric practice. BMJ 1:562-64.
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Schwentker FF, Waghelstein J (1938)
A note on the use of sulfanilamide in scarlet fever. Baltimore Health News 15:41-44.
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Snodgrass WR, Anderson T, Rennie JL (1938)
Sulphamido-chrysoidine, sulphanilamide, and benzylsulphanilamide in the treatment of erysipelas. BMJ 2:399-403.
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Bowie FJ (1938)
Chemotherapy in gonorrhoea: a preliminary report on the use of 2-(p-aminobenzenesulphonamido)pyridine, M & B 693. BMJ 2:283-284.
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Anderson T (1939)
Sulphanilamide in the treatment of measles. BMJ 1:716-718.
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Banks HS (1939)
Chemotherapy of meningococcal meningitis. Lancet 2:921-927.
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Benn EC (1939)
Sulphanilamide in the treatment of scarlet fever. BMJ 2:644-646.
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Cutts M, Gormly CF, Burgess AM (1939)
The treatment of lobar pneumonia with sulfapyridine. New England Journal of Medicine 221:263-266.
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Dub LA, Lurie LA (1939)
Use of benzedrine in the depressed phase of the psychotic state. Ohio State Medical Journal 35:39-45.
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Evans W, Loughman O (1939)
The drug treatment of hyperpiesia. British Heart Journal 1:199-228.
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Farnworth Anderson T, Dowdeswell RM (1939)
Treatment of pneumonia with M. & B. 693. Lancet 1:252-255.
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Graham D, Warner WP, Dauphinée JA, Dickson RC (1939)
The treatment of pneumococcal pneumonia with Dagenan (M&B 693). Canadian Medical Association Journal 40:325-332.
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Master AM, Jaffe HL, Dack S (1939)
The drug treatment of angina pectoris due to coronary artery disease. American Journal of Medical Science 197:774-782.
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Pasricha CL, de Monte AJH, Chatterjee BC, Mian AS (1939)
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Donald JF, Molla AL (1978)
A controlled study comparing a three times daily dose of chlordiazepoxide with a single night-time dose of Trancopal in the control of anxiety, using a double-blind, double-dummy technique. J Int Med Res 6:105-10.
View
Hemminki E, Starfield B (1978)
Prevention and treatment of premature labour by drugs: review of controlled clinical trials. British Journal of Obstetrics and Gynaecology 85:411-417.
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Jick H, Vessey M (1978)
Case-control studies in the evaluation of drug-induced illness. American Journal of Epidemiology 1978;107:1-7.
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Rhind VM, Leatham PA, Wright V, Akbar FA, Downie WW (1978)
A comparative study of floctafenine (Idarac) and ibuprofen in the treatment of osteoarthrosis. Journal of International Medicial Research 2:11-13.
View
The Pooling Project Research Group (1978)
Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events: Final report of the Pooling Project. Journal of Chronic Diseases 31:210-306.
View
Winship DH (1978)
Cimetidine in the treatment of duodenal ulcer: Review and commentary. Gastroenterology 74:402-406.
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Blohmé G, Waldenström J (1979)
Glibenclamide and glipizide in maturity onset diabetes. A double-blind cross-over study. Acta Medica Scandinavica 206:263-7.
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Mirakhur RK, Dundee JW, Connolly JD (1979)
Studies of drugs given before anaesthesia. XVII: anticholinergic premedicants. British Journal of Anesthesia 51:339-45.
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Coronary Drug Project Research Group (1980)
Influence of adherence to treatment and response of cholesterol on mortality in the coronary drug project. New England Journal of Medicine 303:1038-41.
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Editorial (1980)
Aspirin after myocardial infarction. Lancet 1:1172-3.
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Hemminki E (1980)
Study of information submitted by drug companies to licensing authorities. BMJ 280:833-6.
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Baum ML, Anish DS, Chalmers TC, Sacks HS, Smith H, Fagerstrom RM (1981)
A survey of clinical trials of antibiotic prophylaxis in colon surgery: Evidence against further use of no-treatment controls. New England Journal of Medicine 305:795-799.
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DeSilva RA, Hennekens CH, Lown B, Cassells W (1981)
Lignocaine prophylaxis in acute myocardial infarction: An evaluation of randomised trials. Lancet 17:855-858.
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Hemminki E (1981)
Quality of reports of clinical trials submitted by the drug industry to the Finnish and Swedish control authorities. European Journal of Clincal Pharmacology 19:157-165.
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Loeliger EA (1981)
Oral anticoagulation in the secondary prevention of myocardial infarction. Acta Medica Scandinavica 651(suppl):305-315.
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Polk BF (1981)
Antimicrobial prophylaxis to prevent mixed bacterial infection. Journal of Antimicrobial Chemotherapy 8(suppl D):115-129.
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Andrews G, MacMahon SW, Austin A, Byrne DG (1982)
Hypertension: comparison of drug and non-drug treatments. BMJ 284:1523-1526.
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Baber NS, Lewis JA (1982)
Confidence in results of beta-blocker postinfarction trials. BMJ 284: 1749-1750.
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Cone LA (1982)
A survey of prospective, controlled clinical trials of gentamicin, tobramycin, amikacin, and netilmicin. Clinical Therapeutics 5:155-1621.
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Editorial (1982)
Long-term and short-term beta-blockade after myocardial infarction. Lancet 1:1159-1161.
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Hampton JR (1982)
Should every survivor of a heart attack be given a beta-blocker? Part I Evidence from clinical trials. BMJ 285:33-36.
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Kavale K (1982)
The efficacy of stimulant drug treatment for hyperactivity: A metaanalysis. Journal of Learning Disabilities 15:280-289.
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Lewis JA (1982)
Beta-blockade after myocardial infarction- a statistical view. Br J Clin Pharmac 14:15S-21S.
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Robert E, Guibaud P (1982)
Maternal valproic acid and congenital neural tube defects. Lancet 2:937.
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Stampfer MJ, Goldhaber SZ, Yusuf S, Peto R, Hennekens CH (1982)
Effect of intravenous streptokinase on acute myocardial infarction: pooled results from randomized trials. New England Journal of Medicine 307:1180-1182.
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Venning GR (1982)
Validity of anecdotal reports of suspected adverse drug reactions: the problem of false alarms. BMJ 284:249-254.
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May GS, Eberlein KA, Furberg CD, Passamani ER, DeMets DL (1982)
Secondary prevention after myocardial infarction: A review of long-term trials. Progress in Cardiovascular Diseases 24:331–352.
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Baber NS, Lewis JA (1983)
Beta-adrenoreceptor blockade and myocardial infarction: When should treatment start and for how long should it continue? Circulation 67(suppl I):I-71-I-75.
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Canner PL (1983)
Aspirin in coronary heart disease. Comparison of six clinical trials. Israel Journal of Medical Sciences 19:413-423.
View
Foon KA, Smalley RV, Riggs CW, Gale RP (1983)
The role of immunotherapy in acute myelogenous leukemia. Arch Intern Med 143: 1726-1731
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Furberg CD, Bell RL (1983)
Effect of beta-blocker therapy on recurrent nonfatal myocardial infarction. Circulation 67 (suppl I): I-83-I-85.
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Huitfeldt B, Montgomery SA (1983)
Comparison between zimeldine and amitriptyline of efficacy and adverse symptoms~a combined analysis of four British clinical trials in depression. Acta Psychiatr Scand (suppl) 308:55-69.
View
Leizorovicz A, Boissel JP (1983)
Oral anticoagulant in patients surviving myocardial infarction. A new approach to old data. European Journal of Clinical Pharmacology 24:333-336.
View
Messer J, Reitman D, Sacks HS, Smith H, Chalmers TC (1983)
Association of adrenocorticosteroid therapy and peptic-ulcer disease. The New England Journal of Medicine 309(1):21-24.
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Moskowitz G, Chalmers TC, Sacks HS, Fagerstrom RM, Smith H Jr (1983)
Deficiencies of clinical trials of alcohol withdrawal. Alcoholism 7:42-46.
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Thurber S, Eugene Walker C (1983)
Medication and hyperactivity: A meta-analysis. The Journal of General Psychology 108:79-86.
View
Yusuf S, Sleight P (1983)
Limitation of myocardial infarct size. Present status. Drugs 25:441-450.
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Bassan MM, Shalev O, Eliakim A (1984)
Improved prognosis during long-term treatment with beta-blockers after myocardial infarction: Analysis of randomized trials and pooling of results. Heart Lung 13:164-168.
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Gehlbach SH, Wilkinson WE, Hammond WE, Clapp NE, Finn AL, Taylor WJ, Rodell M (1984)
Improving drug prescribing in a primary care practice. Medical Care 22:193-201.
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King JF, Keirse MJNC, Grant A, Chalmers I (1985)
Tocolysis - the case for and against. In: Beard RW, Sharp F, eds. Preterm Labour and its Consequences. London: Royal College of Obstetricians and Gynaecologists, 1985:199-208.
View
Kornitzer M, Rose G (1985)
WHO European Collaborative Trial of multifactorial prevention of coronary heart disease. Preventive Medicine 14:272-8.
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Sacks HS, Chalmers TC, Berk AA, Reitman D (1985)
Should mild hypertension be treated? An attempted meta-analysis of the clinical trials. Mount Sinai Journal of Medicine 52:265-270.
View
Yusuf S, Peto R, Lewis J, Collins R, Sleight P (1985)
Beta blockade during and after myocardial infarction: an overview of the randomized trials. Progress in Cardiovascular Disease 27:335-371.
View
Gracely RH, Dubner R, Deeter WR, Wolskee PJ (1985)
Clinicians’ expectations influence placebo analgesia. Lancet 325:43. DOI:https://doi.org/10.1016/S0140-6736(85)90984-5
View
Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI) (1986)
Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1: 397-402.
View
Himel HN, Liberati A, Gelber RD, Chalmers TC (1986)
Adjuvant chemotherapy for breast cancer: A pooled estimate based on results from published randomized control trials. JAMA 256:1148-1159.
View
Peto J, Eden OB, Lilleyman J, Richards S (1986)
Improvement in treatments for children with acute lymphoblastic leukaemia: The Medical Research Council UKALL Trials, 1972-84. Lancet 1:408-411.
View
Simes RJ (1986)
Publication bias: the case for an international registry of clinical trials. Journal of Clinical Oncology 4:1529-41.
View
Herxheimer A, Zentler-Munro P, Winn D (1986)
Therapeutic trials and society: making the best use of resources. London: Consumers Association.
View
ISIS-1 (first International Study of Infarct Survival) Collaborative Group (1986)
Randomised trial of intravenous atenolol among 16 027 cases of suspected acute myocardial infarction: ISIS-1. First International Study of Infarct Survival Collaborative Group. Lancet 2:57-66.
View
Gøtzsche PC (1987)
Reference bias in reports of drug trials. BMJ 295:654-656.
View
Machin D, Campbell MJ (1987)
Statistical Tables for the Design of Clinical Trials. Oxford: Blackwell scientific publications.
View
Antiplatelet Trialists' Collaboration (1988)
Secondary prevention of vascular disease by prolonged anti-platelet treatment. BMJ 296:320-331.
View
Chalmers I, ed (1988)
The Oxford Database of Perinatal Trials. Oxford: Oxford University Press.
View
Early Breast Cancer Trialists' Collaborative Group (1988)
Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. An overview of 61 randomized trials among 28,896 women. New England Journal of Medicine 319:1681-92.
View
Elbourne D, Prendiville W, Chalmers I (1988)
Choice of oxytocic preparation for routine use in the management of the third stage of labour: an overview of the evidence from controlled trials. British Journal of Obstetrics and Gynaecology 95:17-30.
View
Farr BM, Hendley JO, Kaiser DL, Gwaltney JM (1988)
Two randomized controlled trials of virucidal nasal tissues in the prevention of natural upper respiratory infections. Am J Epidemiol 128:1162-72.
View
ISIS-2 (second International Study of Infarct Survival) Collaborative Group (1988)
Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17 187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 332:349–360.
View
King JF, Grant A, Keirse MJNC, Chalmers I (1988)
Betamimetics in preterm labour: an overview of the randomized controlled trials. British Journal of Obstetetrics and Gynaecology 95:211-222.
View
MacMahon S, Collins R, Peto R, Koster RW, Yusuf S (1988)
Effects of prophylactic lidocaine in suspected acute myocardial infarction. An overview of results from the randomized, controlled trials. JAMA 260:1910-6.
View
Prendiville W, Elbourne E, Chalmers I (1988)
The effects of routine oxytocic administration in the management of the third stage of labour: an overview of the evidence from controlled trials. British Journal of Obstetrics and Gynaecology 95:3-16.
View
Chalmers I, Enkin M, Keirse MJNC (1989)
Effective care in pregnancy and childbirth. Oxford: Oxford University Press.
View
Gyorkos TW, Frappier-Davignon L, MacLean JD, Viens P (1989)
Effect of screening and treatment on imported intestinal parasite infections: results from a randomized, controlled trial. American Journal of Epidemiology 129:753-61.
View
Hine LK, Laird N, Hewitt P, Chalmers TC (1989)
Meta-analytic evidence against prophylactic use of lidocaine in acute myocardial infarction. Archives of Internal Medicine 149:2694-8.
View
Gøtzsche PC (1989)
Methodology and overt and hidden bias in reports of 196 double-blind trials of nonsteroidal antiinflammatory drugs in rheumatoid arthritis. Control Clinical Trials 10:31-56.
View
Crowley P, Chalmers I, Keirse MJNC (1990)
The effects of corticosteroid administration before preterm delivery: an overview of the evidence from controlled trials. British Journal of Obstetrics & Gynaecology. 97:11–25.
View
Early Breast Cancer Trialists' Collaborative Group (1990)
Treatment of early breast cancer. Vol 1. Worldwide evidence, 1985-1990. Oxford: Oxford University Press.
View
Bartlett AV, Englender SJ, Jarvis BA, Ludwig L, Carlson JF, Topping JP (1991)
Controlled trial of Giardia lamblia: Control strategies in day care centers. American Journal of Public Health 81:1001-1006.
View
Advanced Ovarian Cancer Trialists Group (1991)
Chemotherapy in advanced ovarian cancer: an overview of randomised clinical trials. BMJ 303:884-893.
View
Antman EM, Lau J, Kupelnick B, Mosteller F, Chalmers TC (1992)
A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. JAMA 268:240-248.
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Sinclair JC, Bracken MB (1992)
Effective care of the newborn infant. Oxford: Oxford University Press.
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Cowley AJ, Skene A, Stainer, Hampton JR (1993)
The effect of lorcainide on arrhythmias and survival in patients with acute myocardial infarction. International Journal of Cardiology 40:161-166.
View
Cochrane Pregnancy and Childbirth Group (1994)
The Cochrane Pregnancy and Childbirth Database. Oxford: Update Software
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Cholesterol Treatment Trialists’ (CTT) Collaboration (1995)
Protocol for a prospective collaborative overview of all current and planned randomized trials of cholesterol treatment regimens. American Journal of Cardiology 75:1130-1134.
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Higgins JPT, Whitehead A (1996)
Borrowing strength from external trials in a meta-analysis. Statistics in Medicine 15:2733-2749.
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Zucker DR, Schmid CH, McIntosh MW, D'Agostino RB, Selker HP, Lau J (1997)
Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment. Journal of Clinical Epidemiology 50:410-410.
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Waller LA (1997)
A note on Harold S Diehl, randomization, and clinical trials. Controlled Clinical Trials 18: 180-183.
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Murray DM (1998)
Design and Analysis of Group Randomized Trials. New York: Oxford University Press Inc.
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Mahon JL, Laupacis A, Hodder RV, McKim DA, Paterson NA, Wood TE, Donner A (1999)
Theophylline for irreversible chronic airflow limitation: a randomized study comparing n of 1 trials to standard practice. Chest 115:38-48. PMID: 9925061
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Djulbegovic B, Lacevic M, Cantor A, Fields KK, Bennett CL, Adams JR, Kuderer NM, Lyman GH (2000)
The uncertainty principle and industry-sponsored research. Lancet 356:635-638.
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Yusuf S (2000)
Challenges in the conduct and interpretation of phase II (pilot) randomized trials. . American Heart Journal 139:S136-42.
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Stangl D, Berry DA (2000)
Meta-Analysis in Medicine and Health Policy. New York: Marcel Dekker, Inc.
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Sutton AJ, Abrams KR, Jones DR, Sheldon T, Song F (2000)
Methods for Meta-Analysis in Medical Research. Chichester: Wiley.
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Horn J (2001)
Calcium antagonists in Stroke. ISBN 90-9014236-3.
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Wagner AK, Soumerai SB, Zhang F, Ross-Degnan D (2002)
Segmented regression analysis of interrupted time series studies in medication use research. Journal of Clinical Pharmacy and Therapeutics 27:299–309.
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Sandercock P, Roberts I (2002)
Systematic reviews of animal experiments. Lancet 360:586. DOI:https://doi.org/10.1016/S0140-6736(02)09812-4.
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Melander H, Ahlqvist-Rastad J, Meijer G, Beermann B (2003)
Evidence b(i)ased medicine - selective reporting from studies sponsored by pharmaceutical industry: review of studies in new drug applications. BMJ 326:1171-3.
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Wager E, Field EA, Grossman L (2003)
Good Publication Practice for pharmaceutical companies. Current Medical Research and Opinion 19:149-54.
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Jones B, Kenward MG (2003)
Design and Analysis of Cross-Over-Trials (2nd Ed). London and USA: Chapman and Hall.
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Psaty BN, Lumley T, Furberg CD, Schellenbaum G, Pahor M, Alderman MH, Weiss NS (2003)
Health outcomes associated with various antihypertensive therapies used as first-line agents - a network meta-analysis. JAMA 289:2534-2544
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Whittington CJ, Kendall T, Fonagy P, Cottrell D, Cotgrove A, Boddington E (2004)
Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data. Lancet; 363:1341-1345.
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O'Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW (2006)
1,026 experimental treatments in acute stroke. Annals of Neurology 59:467-77. https://doi.org/10.1002/ana.20741
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Perel P, Roberts I, Sena E, Wheble P, Briscoe C, Sandercock S, Macleod M, Mignini LE, Jayaram P, Khan KS (2007)
Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ 334:197-200.
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Glasziou P, Chalmers I, Rawlins M, McCulloch P (2007)
When are randomised trials unnecessary? Picking signal from noise. BMJ 334: 349-351.
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Psaty BM, Kronmal RA (2008)
Reporting mortality findings in trials of Rofecoxib for Alzheimer disease or cognitive impairment. JAMA 299:1813-1817.
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Djulbegovic B, Kumar A, Soares HP, Hozo I, Bepler G, Clarke M, Bennett CL (2008)
Treatment success in cancer: new cancer treatment successes identified in phase 3 randomized controlled trials conducted by the national cancer institute-sponsored cooperative oncology groups, 1955 to 2006. Archives of Internal Medicine. 168:632-42.
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Rising K, Bacchetti P, Bero L (2008)
Reporting bias in drug trials submitted to the Food and Drug Administration: review of publication and presentation. PLoS Med 5(11): e217. doi:10.1371/journal.pmed.0050217
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Trotta F, Apolone G, Garattini S, Tafuri G (2008)
Stopping a trial early in oncology: for patients or for industry? Annals of Oncology Feb 29; doi:10.1093/annonc/mdn042.
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Turner EH, Matthews AM, Linardatos E, Tell RA, Rosenthal R (2008)
Selective publication of antidepressant trials and its influence on apparent efficacy. New England Journal of Medicine 358:252-60.
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Sena ES, Briscoe CL, Howells DW, Donnan GA, Sandercock PA, Macleod MR (2010)
Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis. Journal of Cerebral Blood Flow and Metabolism 30:1905-13.
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Sena ES, van der Worp HB, Bath PMW, Howells DW, Macleod MR (2010)
Publication bias in reports of animal Stroke studies leads to major overstatement of efficacy. PLoS Biol 8(3): e1000344. doi:10.1371/journal.pbio.1000344
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Prinz F, Schlange T, Asadullah K (2011)
Believe it or not: how much can we rely on published data on potential drug targets? Nat Rev Drug Discov 10:712.
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Turner EH, Knoepflmacher D, Shapley L (2012)
Publication bias in antipsychotic trials: an analysis of efficacy comparing the published literature to the US Food and Drug Administration database. PLoS Med 9(3):e1001189.
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Goldacre B (2012)
Bad Pharma: how drug companies mislead doctors and harm patients. London: Fourth Estate.
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Jefferson T, Jones MA, Doshi P, Del Mar CB, Hama R, Thompson MJ, Spencer EA, Onakpoya I, Mahtani KR, Nunan D, Howick J, Heneghan CJ (2014)
Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database of Systematic Reviews 2014, Issue 4. Art. No.: CD008965. DOI:10.1002/14651858.CD008965.pub4.
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Sena ES, Currie GL, McCann SK, Macleod MR, Howells DW (2014)
Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically. J Cereb Blood Flow Metab 34:737-742. doi:10.1038/jcbfm.2014.28
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Punja S, Xu D, Schmid CH, Hartling L, Urichuk L, Nikles CJ, Vohra S (2016)
N of 1 trials can be aggregated to generate group mean treatment effects: A systematic review and meta-analysis. Journal of Clinical Epidemiology 76:65-75.
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de Vries YA, Roest AM, de Jonge P, Cuijpers P, Munafò MR, Bastiaansen JA (2018)
The cumulative effect of reporting and citation biases on the apparent efficacy of treatments: the case of depression. Psychological Medicine 48:2453-2455.
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Horby P, Lim WS, Emberson J, Mafham M, Bell J, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B, Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffrey K, Montgomery A, Rowan K, Juszcak E, Baillie JK, Haynes R, Landray MJ, on behalf of the RECOVERY Collaborative Group (2020)
Effect of Dexamethasone in Hospitalized Patients with COVID-19: Preliminary Report. medRχiv. Doi: https://doi.org/10.1101/2020.06.22.20137273
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Horby P, Mafham M, Linsell L, Bell JL, Staplin N, Emberson JR, Wiselka M, Ustianowski A, Elmahi E, Prudon B, Whitehouse A, Felton T, Williams J, Faccenda J, Underwood J, Baillie JK, Chappell L, Faust SN, Jaki T, Jeffery K, Lim WS, Montgomery A, Rowan K, Tarning J, Watson JA, White NJ, Juszczak E, Haynes R, Landray MJ (2020)
Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial. doi: https://doi.org/10.1101/2020.07.15.20151852
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RECOVERY Trial Team (2020)
Randomized Evaluation of COVID019 Therapy (RECOVERY). RECOVERY Central Coordinating Office, Oxford. www.recoverytrial.net
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Pan H, Peto R, Karim QA, Alejandria M, Henao-Restrepo AM, García CH, Kieny MP, Malekzadeh R, Murthy S, Preziosi MP, Reddy S, Periago MR, Sathiyamoorthy V, Røttingen JA, Swaminathan S, WHO Solidarity trial consortium (2020)
Repurposed antiviral drugs for COVID-19 –interim WHO SOLIDARITY trial results. MedRxiv. doi: https://doi.org/10.1101/2020.10.15.20209817
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D'Aquila RT, Hughes MD, Johnson VA, Fischl MA, Sommadossi JP, Liou SH, Timpone J, Myers M, Basgoz N, Niu M, Hirsch MS (2021)
Nevirapine, zidovudine, and didanosine compared with zidovudine and didanosine in patients with HIV-1 infection. A randomized, double- blind, placebo-controlled trial. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group Protocol 241 Investigators. Annals of Internal Medicine 124:1019-1030.
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Hahn RA, Teutsch SM (2021)
Saving lives by modifying the process of science: Estimated historical mortality associated with the failure to conduct routine prospective cumulative systematic reviews. American Journal of Biomed Science and Research 14(6):531-534.
View
Show
ALL ARTICLES
Brief histories
Commentaries
Biographies
Personal reflections
Doctoral theses
Yoshioka AY (1998).
Streptomycin, 1946: British central administration of supplies of a new drug of American origin with special reference to clinical trials in tuberculosis. Philosophy Thesis, University of London. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Loudon I (2002).
The use of historical controls and concurrent controls to assess the effects of sulphonamides, 1936-1945. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Scadding JG (2002).
Reflections on my studies of the effects of sulphonamide drugs in bacillary dysentery in Egypt, 1943-1944. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Doll R (2003).
Controlled trials testing two or more treatments simultaneously. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Gong Y, Gluud C (2003).
Commentary on the Ben Cao Tu Jing (11th century). Atlas of Materia Medica. Song Dynasty (960-1279). JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Rolls R (2003).
Caleb Hillier Parry (1755-1822). JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Silverman WA† (2003).
Personal reflections on lessons learned from randomized trials involving newborn infants, 1951 to 1967. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Tröhler U (2003).
Withering’s 1785 appeal for caution when reporting on a new medicine. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Vandenbroucke JP (2003).
Thalidomide: an unanticipated adverse effect. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Vandenbroucke JP (2003).
Aspirin: an unanticipated beneficial effect. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Armitage P† (2003).
Some recollections of the early years of the Medical Research Council (MRC) Statistical Research Unit. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Bastian H (2004).
Down and almost out in Scotland: George Orwell, tuberculosis and getting streptomycin in 1948. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Clarke M (2004).
The 1944 patulin trial of the British Medical Research Council: an example of how concerted common purpose can get reliable answers to important questions very quickly. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Diaz M, Neuhauser D (2004).
Lessons from using randomization to assess gold treatment for tuberculosis. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Elwood P (2004).
The first randomized trial of aspirin for heart attack and the advent of systematic overviews of trials. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Hampton J (2004).
An early parallel group trial in cardiology. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Houston C (2004).
Ferguson’s BCG research – Canada’s first randomized clinical trial? JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Lee MR (2004).
The miracle of St. Alfege’s: discovering a treatment for myaesthenia gravis. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Crofton J† (2005).
Marc Daniels (1907-1953), a pioneer in establishing standards for clinical trial methods and reporting. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Hemminki E (2005).
Commentary on an early placebo controlled trial in Finland. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Lee MR (2005).
William Withering (1741-1799), a biographical sketch of a Birmingham Lunatic. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Volmink J (2005).
The willow as a Hottentot (Khoikhoi) remedy for rheumatic fever. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Boren SA, Diaz M, Neuhauser D (2006).
James Burns Amberson (1890-1979). JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Craft A (2006).
James Stansfeld (1917-1998). JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Crofton J† (2006).
John Crofton (1912-2009). JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Neuhauser D, Diaz M (2006).
Jesse GM Bullowa (1879-1943). JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Tansey EM (2006).
Philip Montagu D’Arcy Hart (1900-2006). JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Louis-Courvoisier M (2007).
An 18th century controlled trial prompted by a potential shortage of hospital beds. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Nasser M, Tibi A, Savage-Smith E (2007).
Ibn Sina’s Canon of Medicine: 11th century rules for assessing the effects of drugs. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Adams CE (2009).
James Crichton Browne and controlled evaluation of drug treatment for mental illness. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Armitage P† (2009).
A statistical note on the analysis of the 1948 MRC streptomycin trial. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Chalmers I, Toth B (2009).
19th century controlled trials to test whether belladonna prevents scarlet fever. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Furberg CD (2009).
How should one analyse and interpret clinical trials in which patients don’t take the treatments assigned to them? JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Moore W (2009).
John Hunter: learning from natural experiments, ‘placebos’, and the state of mind of a patient in the 18th century. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Moore W (2009).
John Hunter (1728-1793). JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Williams KJ (2009).
The introduction of ‘chemotherapy’ using arsphenamine – the first magic bullet. JLL Bulletin: Commentaries on the history of treatment evaluation.
View
Chalmers I (2010).
Why the 1948 MRC trial of streptomycin used treatment allocation based on random numbers. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Cook H (2010).
Testing the effects of Jesuit’s bark in the Chinese Emperor’s court. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Klingberg MA (2010).
An epidemiologist’s journey from typhus to thalidomide, and from the Soviet Union to Seveso. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Spain P, Kadan-Lottick N (2010).
Observations of unprecedented remissions following novel treatment for acute leukemia in children in 1948. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Doyle D (2011).
Thomas John MacLagan (1838-1903). JLL Bulletin: Commentaries on the history of treatment evaluation.
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Doyle D (2011).
Thomas MacLagan’s 1876 demonstration of the dramatic effects of salicin in rheumatic fever. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Fox DM (2011).
Systematic reviews and health policy: the influence of a project on perinatal care since 1988. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Gartlehner G, Stepper K (2011).
Julius Wagner-Jauregg: pyrotherapy, Simultanmethode, and ‘racial hygiene’. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Maehle A-H (2011).
Four early clinical studies to assess the effects of Peruvian bark. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Marušić A, Fatović-Ferenčić S (2012).
Adoption of the double dummy trial design to reduce observer bias in testing treatments. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Milne I (2012).
Who was James Lind, and what exactly did he achieve? JLL Bulletin: Commentaries on the history of treatment evaluation.
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Gachelin G (2013).
The interaction of scientific evidence and politics in debates about preventing malaria in 1925. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Bryder L (2014).
The Medical Research Council and treatments for tuberculosis before streptomycin. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Dean ME (2014).
The mustard gas experiments done by the British Homoeopathic Society for the Ministry of Home Security, 1941-42. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Tröhler U (2014).
Statistics and the British controversy about the effects of Joseph Lister’s system of antisepsis for surgery, 1867-1890. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Hampton J (2015).
Therapeutic fashion and publication bias: the case of anti-arrhythmic drugs in heart attack. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Sackett DL† (2015).
Why did I become a clinician-trialist? JLL Bulletin: Commentaries on the history of treatment evaluation.
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Toth B (2015).
Why the MRC Therapeutic Trials Committee didn’t introduce controlled clinical trials. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Schlesselman JJ (2015).
Jerome Cornfield’s Bayesian approach to assessing interim results in clinical trials. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Gachelin G, Garner P, Ferroni E, Tröhler U, Chalmers I (2016).
Evaluating Cinchona bark and quinine for treating and preventing malaria. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Peto J (2016).
Reflections on the importance of strict adherence to treatment protocols: acute lymphoblastic leukaemia in children in the 1970s in the US and the UK. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Peto R (2016).
Reflections on the design and analysis of clinical trials and meta-analyses in the 1970s and 1980s. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Zwarenstein M (2016).
‘Pragmatic’ and ‘Explanatory’ attitudes to randomized trials. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Senn SJ (2017).
Cushny and Peebles, optical isomers, and the birth of modern statistics. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Altman DG† (2017).
Donald Mainland: anatomist, educator, thinker, medical statistician, trialist, rheumatologist. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Altman DG† (2017).
Avoiding bias in trials in which allocation ratio is varied. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Pollock JI (2017).
A controlled trial using a factorial design reported in 1946. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Toth B (2018).
Pioneering controlled trials of treatments for erysipelas and pneumonia in Glasgow, 1936-47. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Garattini S (2018).
Italian controlled trials to assess prevention and treatment of malaria, 1900-1930s. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Tognoni G, Franzosi MG, Garattini S (2018).
Embedding patient- and public health-oriented research in a national health service: the GISSI experience. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Marson Smith P, Colquhoun D, Chalmers I (2019).
John Henry Gaddum’s 1940 guidance on controlled clinical trials JLL Bulletin: Commentaries on the history of treatment evaluation.
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Meinert C† (2019).
The trials and tribulations of the University Group Diabetes Program: lessons and reflections. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Jefferson T (2019).
Sponsorship bias in clinical trials – growing menace or dawning realisation? JLL Bulletin: Commentaries on the history of treatment evaluation.
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Tröhler U (2020)
Probabilistic thinking and the evaluation of therapies, 1700-1900. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Glasziou PP, Tikkinen KAO (2021).
The RECOVERY trial platform: a milestone in the development and execution of treatment evaluation during an epidemic. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Senn SJ, Chalmers I (2021).
Giving and taking: ethical treatment assignment in controlled trials. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Gøtzsche PC (2021).
Citation bias: questionable research practice or scientific misconduct? JLL Bulletin: Commentaries on the history of treatment evaluation.
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Ritskes-Hoitinga M, Pound P (2022).
The role of systematic reviews in identifying the limitations of preclinical animal research, 2000 – 2022. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Podolsky SH (2022).
The (Harry) Gold Standard: angina, suggestion, and the path to the “double-blind” test and Clinical Pharmacology. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Chalmers I, Matthews R, Glasziou P, Boutron I, Armitage P† (2023).
Analysis of clinical trial by Treatment Allocated or by Treatment Received? Applying ‘the intention-to-treat principle’. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Nylenna, M (2023).
Paul Owren, Christopher Bjerkelund and the dawn of controlled trials in Norway. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Glasziou P, Matthews R, Boutron I, Chalmers I, Armitage P† (2023)
The differences and overlaps between ‘explanatory’ and ‘pragmatic’ controlled trials: a historical perspective. JLL Bulletin: Commentaries on the history of treatment evaluation.
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