Gewin J (1908)

Chlorkalzium gegen die Serumkrankheit [Calcium chloride against serum sickness]. Muenchener Medizinische Wochenshcrift 50:2670-2671.

Key passage(s)

Gewin-1908-kp1 Gewin-1908-kp2


“Of the 200 patients who were all treated (injected) S p r o n c k‘s  anti-diphtherial serum, one half (even numbers) received calcium, the other half (uneven numbers) [did] not [receive it], without considering gender, age or [the severity of] the throat affection. As much as possible the children were given in the same order the serum which was given on that same date [day]; thereby we wanted to achieve that the children of one of the two groups (categories) did not receive per chance a very poisonous serum. It is well known that the serum from a given horse shows often – frequently only for a short time – more side-effects than the serum from other horses. In order to eliminate these nocuous side-effects, S p o r c k  mixes the sera from several horses and warms them during half an hour up to 56 – 57°C. Of our 200 patients 92 were female and 108 male. The case histories of those who died (9=4.3%) were not considered [for the analysis]. The distribution according to the age was: 1     2     3     4     5     6     7     8     9     10     <10     years 26    31   26   36    24   15    9     8     7      4        14    number Approximately half of the children in each age group received calcium chloride, the other half not.”

Translation by Ulrich Tröhler

JLL Book of EssaysHave you read the James Lind Library's Introduction to Fair Tests of Treatments?

We have edited, updated and abridged all of the Essays from the Library for 2019, and lavishly illustrated them with examples from the history of fair tests of treatments.  Share and enjoy!

Download the PDF