Simes RJ (1986)

Publication bias: the case for an international registry of clinical trials. Journal of Clinical Oncology 4:1529-41.
Simes 1986:  John Simes proposed international registration of all clinical trials after he showed that conclusions about treatments for ovarian cancer differed depending on whether the results of unpublished trials had been taken into account.

Key passage(s)

Simes_1986_kp_1 Simes_1986_kp_2 Simes_1986_kp_3


John Simes


JLL Book of EssaysHave you read the James Lind Library's Introduction to Fair Tests of Treatments?

We have edited, updated and abridged all of the Essays from the Library for 2019, and lavishly illustrated them with examples from the history of fair tests of treatments.  Share and enjoy!

Download the PDF