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James Lind Library
Illustrating the development of fair tests of treatments in health care
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Appelbaum E, Nelson J, Albin MB (1949)
The treatment of penumococcic meningitis with penicillin; a study of 125 consecutive cases, with 73% recovery. American Journal of Medicial Science 218:260-4.
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Whole article
RELEVANT TOPICS
Treatment comparisons are essential
All topics
Fair tests of treatments
The need to address treatment uncertainties
Treatment comparisons are essential
Placebo effects
Treatment comparisons must be fair
Biases
Design bias
Allocation bias
N-of-1 crossover
Cluster allocation
Crossover tests
Factorial design
Co-intervention bias
Observer bias
Double dummy
Analysis bias
Biases in judging unanticipated possible effects
Reporting bias
Biases in systematic reviews
Researcher/sponsor bias and fraud
The play of chance
Recording and interpreting numbers
Quantifying uncertainty
Using meta-analysis
Bringing it all together for the benefit of patients and the public
Improving reports of research
Preparing and maintaining systematic reviews
Using the results of research
