Cousin M (1905) - The James Lind Library The James Lind Library

Cousin M (1905)

Des éruptions consecutives aux injections de sérum antidiphthérique et de leur traitement prophylactique par l’ingestion de clorure de calcium. Thèse pour le Doctorat en médicine. Paris : Jules Rousset, 36-44.
In 1905, the French investigators Cousin and Netter used ‘la système alternante’ to generate comparison groups to test the effects of calcium chlorate in reducing serum sickness among children receiving anti-diphtheritic serum.

Title page(s)

Key passage(s)

Whole article

RELEVANT TOPICS

Allocation bias

Key articles

Gluud C (2010).
Danish contributions to the evaluation of serum therapy for diphtheria in the 1890s.
Opinel A, Gachelin G (2010).
French 19th century contributions to the development of treatments for diphtheria.

Other articles

Chalmers I (2010).
Why the 1948 MRC trial of streptomycin used treatment allocation based on random numbers.
Chalmers I, Dukan E, Podolsky SH, Davey Smith G (2011).
The advent of fair treatment allocation schedules in clinical trials during the 19th and early 20th centuries.

All topics

Website by Minervation Ltd, supported by the James Lind Initiative and the Presidential Fund of the Swiss National Science Foundation.