Perel P, Roberts I, Sena E, Wheble P, Briscoe C, Sandercock S, Macleod M,  Mignini LE, Jayaram P, Khan KS (2007)

Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ 334:197-200.
In 2007, Pablo Perel and his colleagues addressed longstanding questions about the validity of animal models for developing treatments for patients. They demonstrated both concordance and discordance between the results of studies in animals and humans.

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The editors are grateful to:

BMJ for allowing the James Lind Library to link to this and other BMJ articles of historical relevance (email to Iain Chalmers from Fiona Godlee, 05 May 2015).