Doll R, Pygott F (1952)

Factors influencing the rate of healing of gastric ulcers: admission to hospital, phenobarbitone, and ascorbic acid. Lancet 1: 171-175.
As trial design became more sophisticated, the factorial trial of treatments for gastric ulcers reported in 1952 by the British physicians Richard Doll and Frank Pygott provided an early illustration of how more than one treatment could be compared with placebo in a single trial.

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 Richard Doll (1912-2005)



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Elsevier Ltd. for making a pdf of this article available (letter to Iain Chalmers from Laura Pritchard, 14 May 2014). For conditions of further reproduction, see here.