Medical Research Council (1948)
Streptomycin treatment of pulmonary tuberculosis: a Medical Research Council investigation. BMJ 2:769-782.
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Key passage(s)

MRC_strepto_title

MRC_strepto_text

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Portrait(s)

 Austin Bradford Hill (1897-1991)

hill_portrait

Video / Audio

Recording of Sir Austin Bradford Hill

This audio file contains a recording of Sir Austin Bradford Hill reflecting on the MRC randomized trial of streptomycin for pulmonary tuberculosis. It was recorded on Friday 8 September 1989, at the request of Bradford Hill’s friend, William Silverman, who subsequently arranged for the text to be transcribed and published (“Memories of the British Streptomycin Trial in Tuberculosis,” Controlled Clinical Trials 1990;11:77-9). The editors of the James Lind Library are indebted to William Silverman and Tony Johnson, who is responsible for the Bradford Hill Library in Cambridge, for permission to publish the recording (which lasts about 10 minutes).

MRC 1948 (Strep for Pulmonary TB)

 

Extract from Dr Kenneth Citron’s interview of Dr Philip D’Arcy Hart, secretary to the MRC’s Streptomycin Trials Committee, about the MRC trial of streptomycin for pulmonary tuberculosis (with permission from Dr Citron and the Medical Sciences Video Archive at Oxford Brookes University). Philip D’Arcy Hart, Austin Bradford Hill (statistician), Marc Daniels (field coordinator) and Charlene Agnew (administrator) constituted the management team for the trial.

Acknowledgements

The James Lind Library is grateful to:

BMJ for making a free link to the pdf of this article available (email to Iain Chalmers from Fiona Godlee, 05 May 2015).

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  • Armitage P (2009).
    A note on the statistical analysis of the 1948 MRC streptomycin trial.
  • Bastian H (2004).
    Down and almost out in Scotland: George Orwell, tuberculosis and getting streptomycin in 1948.
  • Bryder L (2014).
    The Medical Research Council and treatments for tuberculosis before streptomycin.
  • Chalmers I (2010).
    Why the 1948 MRC trial of streptomycin used treatment allocation based on random numbers.
  • Crofton J (2004).
    The MRC randomized trial of streptomycin and its legacy: a view from the clinical front line.
  • Crofton J (2005).
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  • Scadding JW (2017).
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  • Tansey EM (2006).
    Philip Montagu D’Arcy Hart (1900-2006).

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