Placebo effects

People who believe that a treatment will help to relieve their symptoms may well experience improvements in their condition – even though the treatment, in fact, has no active ingredient.


JLL Essay
1.2 Why treatment comparisons are essential

 

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Papin D (1704)
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Anonymous (1890)
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Riseman JEF, Brown MG (1937)
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Wartolowska K, Judge A, Hopewell S, Collins GS, Dean BJF, Rombach I, Brindley D, Savulescu J, Beard DJ, Carr AJ (2014)
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Wartolowska KA, Collins GS, Hopewell S, Judge A, Dean BJF, Rombach I, Beard DJ, Carr AJ (2016)
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D'Aquila RT, Hughes MD, Johnson VA, Fischl MA, Sommadossi JP, Liou SH, Timpone J, Myers M, Basgoz N, Niu M, Hirsch MS (2021)
Nevirapine, zidovudine, and didanosine compared with zidovudine and didanosine in patients with HIV-1 infection. A randomized, double- blind, placebo-controlled trial. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group Protocol 241 Investigators. Annals of Internal Medicine 124:1019-1030.

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Faltinsen E, Todorovac A, Staxen Bruun L, Hróbjartsson A, Gluud C, Kongerslev MT, Simonsen E, Storebø OJ (2022)
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Laursen DRT, Nejstgaard CH, Bjørkedal E, Frost AD, Hansen MR, Paludan-Müller AS, Prosenz J, Werner CP, Hróbjartsson A. (2023)
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Marson Smith P, Colquhoun D, Chalmers I (2019).
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Senn SJ, Chalmers I (2021).
Giving and taking: ethical treatment assignment in controlled trials. JLL Bulletin: Commentaries on the history of treatment evaluation.

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Podolsky SH (2022).
The (Harry) Gold Standard: angina, suggestion, and the path to the “double-blind” test and Clinical Pharmacology. JLL Bulletin: Commentaries on the history of treatment evaluation.

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Glasziou P, Matthews R, Boutron I, Chalmers I, Armitage P (2023)
The differences and overlaps between ‘explanatory’ and ‘pragmatic’ controlled trials: a historical perspective. JLL Bulletin: Commentaries on the history of treatment evaluation.

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