Park WH (1900)

Use of diphtheria antitoxin in the treatment and prevention of diphtheria. JAMA 34: 902-904.
In 1900, the American physician William Park described his use of alternation  to create comparison groups in a test of the effects of anti-diphtheritic serum in children.

Key passage(s)


Whole article


The editors are grateful to:

JAMA for allowing the James Lind Library to link to this and other articles of historical relevance (email to Iain Chalmers from Annette Flanagin, 29 August 2014).

JLL Book of EssaysHave you read the James Lind Library's Introduction to Fair Tests of Treatments?

We have edited, updated and abridged all of the Essays from the Library for 2019, and lavishly illustrated them with examples from the history of fair tests of treatments.  Share and enjoy!

Download the PDF