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James Lind Library
Illustrating the development of fair tests of treatments in health care
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Lindsey JK, Jones B (1996)
A model for cross-over trials evaluating therapeutic preferences. Statistics in Medicine 15:443–7.
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Key passage(s)
RELEVANT TOPICS
Treatment comparisons are essential
Key articles
Mirza RD, Punja S, Vohra S, Guyatt G (2017).
The history and development of N of 1 trials.
All topics
Fair tests of treatments
The need to address treatment uncertainties
Treatment comparisons are essential
Placebo effects
Treatment comparisons must be fair
Biases
Design bias
Allocation bias
N-of-1 crossover
Cluster allocation
Crossover tests
Factorial design
Co-intervention bias
Observer bias
Double dummy
Analysis bias
Biases in judging unanticipated possible effects
Reporting bias
Biases in systematic reviews
Researcher/sponsor bias and fraud
The play of chance
Recording and interpreting numbers
Quantifying uncertainty
Using meta-analysis
Bringing it all together for the benefit of patients and the public
Improving reports of research
Preparing and maintaining systematic reviews
Using the results of research
