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Park WH (1900)

Use of diphtheria antitoxin in the treatment and prevention of diphtheria. JAMA 34: 902-904.
In 1900, the American physician William Park described his use of alternation to create comparison groups in a test of the effects of anti-diphtheritic serum in children.

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Park WH (1900). Use of diphtheria antitoxin in the treatment and prevention of diphtheria. JAMA 34: 902-904.

Acknowledgements

The editors are grateful to:

JAMA for allowing the James Lind Library to link to this and other articles of historical relevance (email to Iain Chalmers from Annette Flanagin, 29 August 2014).

RELEVANT TOPICS

Allocation bias

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Podolsky SH, Davey Smith G (2011).
Park’s story and Winters’ tale: alternate allocation clinical trials in turn of the Century America.

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Fair tests of treatments
Biases
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Park WH (1900)

Use of diphtheria antitoxin in the treatment and prevention of diphtheria. JAMA 34: 902-904.
In 1900, the American physician William Park described his use of alternation to create comparison groups in a test of the effects of anti-diphtheritic serum in children.

Key passage(s)

Whole article

Acknowledgements

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Key articles

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James Lind LibraryIllustrating the development of fair tests of treatments in health care

Park WH (1900) Use of diphtheria antitoxin in the treatment and prevention of diphtheria. JAMA 34: 902-904. In 1900, the American physician William Park described his use of alternation to create comparison groups in a test of the effects of anti-diphtheritic serum in children.

Key passage(s)

Whole article

Acknowledgements

RELEVANT TOPICS

Key articles

All topics

BROWSE

ABOUT

COPYRIGHT

FEEDBACK

James Lind Library
Illustrating the development of fair tests of treatments in health care

Park WH (1900)

Use of diphtheria antitoxin in the treatment and prevention of diphtheria. JAMA 34: 902-904.
In 1900, the American physician William Park described his use of alternation to create comparison groups in a test of the effects of anti-diphtheritic serum in children.