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James Lind Library
Illustrating the development of fair tests of treatments in health care
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ADDITIONAL METHODS - FACTORIAL DESIGN
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Wilson C, Pollock MR, Harris AD (1945)
Therapeutic trial of methionine in infective hepatitis. BMJ 1:399-401.
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Wilson C, Pollock MR, Harris AD (1946)
Diet in the treatment of infective hepatitis. Lancet 1:881-883.
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Doll R, Pygott F (1952)
Factors influencing the rate of healing of gastric ulcers: admission to hospital, phenobarbitone, and ascorbic acid. Lancet 1: 171-175.
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Chalmers TC, Eckhardt RD, Reynolds WE, Cigarroa JG, Deane N, Reifenstein RW, Smith CW, Davidson CS (1955)
The treatment of acute infectious hepatitis. Controlled studies of the effects of diet, rest, and physical reconditioning on the acute course of the disease and on the incidence of relapses and residual abnormalities. Journal of Clinical Investigation 34: 1163-1235.
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Tebrock HE, Arminio JJ, Johnston JH (1956)
Usefulness of bioflavinoids and ascorbic acid in treatment of common cold. JAMA 162:1227-1233.
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Franz WL, Sands GW, Heyl HL (1956)
Blood ascorbic acid level in bioflavinoid and ascorbic acid therapy of common cold. JAMA 162:1224-1226.
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Peto R (1978)
Clinical trial methodology. Biomedicine 28 (special issue):24-36.
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Pollock JI (2005).
Two controlled trials of supplementary feeding of British school children in the 1920s. JLL Bulletin: Commentaries on the history of treatment evaluation.
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Pollock JI (2017).
A controlled trial using a factorial design reported in 1946. JLL Bulletin: Commentaries on the history of treatment evaluation.
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methods
Principles of testing
Pre-clinical
Dramatic effects
N-of-1 crossover
Crossover tests
Cluster allocation
Factorial design
Double dummy
Placebo effects