N-of-1 crossover

Random allocation for treatment comparisons can be used to compare different treatments given at different times in random order to the same patient.

12 RECORDS
3 ARTICLES

The need to address treatment uncertainties

Principles of Testing

Treatment comparisons are essential

Treatment comparisons must be fair

Biases

Double dummy

The play of chance

Bringing it all together for the benefit of patients and the public

James Lind Library
Illustrating the development of fair tests of treatments in health care

N-of-1 crossover

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3 ARTICLES

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James Lind LibraryIllustrating the development of fair tests of treatments in health care

N-of-1 crossover

SORT date ▲ author

12 RECORDS

3 ARTICLES

Wiseman R (1676) Eight chirugical treatises. London: R Royston, p 123.

Parry CH (1786) Experiments relative to the medical effects of Turkey Rhubarb, and of the English Rhubarbs, No. I and No. II made on patients of the Pauper Charity. Letters and Papers of the Bath Society 11:431-453.

Haygarth J (1800) Of the imagination, as a cause and as a cure of disorders of the body: exemplified by fictitious tractors, and epidemical convulsions. Bath: R. Crutwell.

Hogben L, Sim M (1953) The self-controlled and self-recorded clinical trial for low grade morbidity. British Journal of Preventative and Social Medicine 7,163-179.

Baskerville JC, Toogood JH, Mazza J, Jennings B. (1984) Clinical trials designed to evaluate therapeutic preferences. Statistics in Medicine; 3:45–55.

Guyatt G, Sackett D, Taylor DW, Chong J, Roberts R, Pugsley S (1986) Determining optimal therapy-randomized trials in individual patients. New England Journal of Medicine 314:889-92.

Guyatt GH, Keller JL, Jaeschke R, Rosenbloom D, Adachi JD, Newhouse MT (1990) The n-of-1 randomized controlled trial: clinical usefulness. Our three-year experience. Annals of Internal Medicine 112:293-299.

Lindsey JK, Jones B (1996) A model for cross-over trials evaluating therapeutic preferences. Statistics in Medicine 15:443–7.

Zucker DR, Schmid CH, McIntosh MW, D'Agostino RB, Selker HP, Lau J (1997) Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment. Journal of Clinical Epidemiology 50:410-410.

Davidson I, Hillier VF (2002) Comparison of four methods of allocation for clinical trials with small sample sizes. Physiotherapy 88;12:722-729, ISSN 0031-9406.

Punja S, Xu D, Schmid CH, Hartling L, Urichuk L, Nikles CJ, Vohra S (2016) N of 1 trials can be aggregated to generate group mean treatment effects: A systematic review and meta-analysis. Journal of Clinical Epidemiology 76:65-75.

Show ALL ARTICLES Brief histories Commentaries Biographies Personal reflections Doctoral theses

Howick J (2016).Aulus Cornelius Celsus and ‘empirical’ and ‘dogmatic’ medicine JLL Bulletin: Commentaries on the history of treatment evaluation.

La Rochelle P (2017).Using randomized, double-blind, n-of-1 trials of food challenge to diagnose food allergy and assess the effectiveness of food allergen avoidance. JLL Bulletin: Commentaries on the history of treatment evaluation.

Mirza RD, Punja S, Vohra S, Guyatt G (2017).The history and development of N of 1 trials. JLL Bulletin: Commentaries on the history of treatment evaluation.

Topics

BROWSE

ABOUT

COPYRIGHT

FEEDBACK

James Lind Library
Illustrating the development of fair tests of treatments in health care

Wiseman R (1676)
Eight chirugical treatises. London: R Royston, p 123.

Parry CH (1786)
Experiments relative to the medical effects of Turkey Rhubarb, and of the English Rhubarbs, No. I and No. II made on patients of the Pauper Charity. Letters and Papers of the Bath Society 11:431-453.

Haygarth J (1800)
Of the imagination, as a cause and as a cure of disorders of the body: exemplified by fictitious tractors, and epidemical convulsions. Bath: R. Crutwell.

Hogben L, Sim M (1953)
The self-controlled and self-recorded clinical trial for low grade morbidity. British Journal of Preventative and Social Medicine 7,163-179.

Baskerville JC, Toogood JH, Mazza J, Jennings B. (1984)
Clinical trials designed to evaluate therapeutic preferences. Statistics in Medicine; 3:45–55.

Guyatt G, Sackett D, Taylor DW, Chong J, Roberts R, Pugsley S (1986)
Determining optimal therapy-randomized trials in individual patients. New England Journal of Medicine 314:889-92.

Guyatt GH, Keller JL, Jaeschke R, Rosenbloom D, Adachi JD, Newhouse MT (1990)
The n-of-1 randomized controlled trial: clinical usefulness. Our three-year experience. Annals of Internal Medicine 112:293-299.

Lindsey JK, Jones B (1996)
A model for cross-over trials evaluating therapeutic preferences. Statistics in Medicine 15:443–7.

Zucker DR, Schmid CH, McIntosh MW, D'Agostino RB, Selker HP, Lau J (1997)
Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment. Journal of Clinical Epidemiology 50:410-410.

Davidson I, Hillier VF (2002)
Comparison of four methods of allocation for clinical trials with small sample sizes. Physiotherapy 88;12:722-729, ISSN 0031-9406.

Punja S, Xu D, Schmid CH, Hartling L, Urichuk L, Nikles CJ, Vohra S (2016)
N of 1 trials can be aggregated to generate group mean treatment effects: A systematic review and meta-analysis. Journal of Clinical Epidemiology 76:65-75.

Show

Howick J (2016).
Aulus Cornelius Celsus and ‘empirical’ and ‘dogmatic’ medicine JLL Bulletin: Commentaries on the history of treatment evaluation.

La Rochelle P (2017).
Using randomized, double-blind, n-of-1 trials of food challenge to diagnose food allergy and assess the effectiveness of food allergen avoidance. JLL Bulletin: Commentaries on the history of treatment evaluation.

Mirza RD, Punja S, Vohra S, Guyatt G (2017).
The history and development of N of 1 trials. JLL Bulletin: Commentaries on the history of treatment evaluation.