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James Lind Library
Illustrating the development of fair tests of treatments in health care
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ADDITIONAL METHODS - N-OF-1 CROSSOVER
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Punja S, Xu D, Schmid CH, Hartling L, Urichuk L, Nikles CJ, Vohra S (2016)
N of 1 trials can be aggregated to generate group mean treatment effects: A systematic review and meta-analysis. Journal of Clinical Epidemiology 76:65-75.
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Zucker DR, Schmid CH, McIntosh MW, D'Agostino RB, Selker HP, Lau J (1997)
Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment. Journal of Clinical Epidemiology 50:410-410.
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Lindsey JK, Jones B (1996)
A model for cross-over trials evaluating therapeutic preferences. Statistics in Medicine 15:443–7.
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Guyatt GH, Keller JL, Jaeschke R, Rosenbloom D, Adachi JD, Newhouse MT (1990)
The n-of-1 randomized controlled trial: clinical usefulness. Our three-year experience. Annals of Internal Medicine 112:293-299.
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Guyatt G, Sackett D, Taylor DW, Chong J, Roberts R, Pugsley S (1986)
Determining optimal therapy-randomized trials in individual patients. New England Journal of Medicine 314:889-92.
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Baskerville JC, Toogood JH, Mazza J, Jennings B. (1984)
Clinical trials designed to evaluate therapeutic preferences. Statistics in Medicine; 3:45–55.
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Hogben L, Sim M (1953)
The self-controlled and self-recorded clinical trial for low grade morbidity. British Journal of Preventative and Social Medicine 7,163-179.
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Haygarth J (1800)
Of the imagination, as a cause and as a cure of disorders of the body: exemplified by fictitious tractors, and epidemical convulsions. Bath: R. Crutwell.
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Parry CH (1786)
Experiments relative to the medical effects of Turkey Rhubarb, and of the English Rhubarbs, No. I and No. II made on patients of the Pauper Charity. Letters and Papers of the Bath Society 11:431-453.
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Wiseman R (1676)
Eight chirugical treatises. London: R Royston, p 123.
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Paré A (1575)
1575 Les oeuvres de M. Ambroise Paré conseiller, et premier chirurgien du Roy avec les figures & portraicts tant de l'Anatomie que des instruments de Chirurgie, & de plusieurs Monstres. [The works of M. Ambroise Paré, advisor, and first surgeon to the King, with figures and portraits concerning anatomy as well as surgical instruments, and several monsters] Paris: Gabriel Buon.
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Mirza RD, Punja S, Vohra S, Guyatt G (2017).
The history and development of N of 1 trials. JLL Bulletin: Commentaries on the history of treatment evaluation.
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La Rochelle P (2017).
Using randomized, double-blind, n-of-1 trials of food challenge to diagnose food allergy and assess the effectiveness of food allergen avoidance. JLL Bulletin: Commentaries on the history of treatment evaluation.
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methods
Principles of testing
Pre-clinical
Dramatic effects
N-of-1 crossover
Crossover tests
Cluster allocation
Factorial design
Double dummy
Placebo effects