Analysis bias

Biases can be introduced when knowledge of the results of studies influences analysis and reporting decisions, for example, when studies stop earlier than planned, or with biased selection of the treatment outcomes measured.


JLL Essay
2.5 Bias introduced after looking at study results

Fair measurement of treatment outcome

 

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Bassler D, Briel M, Montori VM, Lane M, Glasziou P, Zhou Q, Heels-Ansdell D, Walter SD, Guyatt GH; STOPIT-2 Study Group (2010)
Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA. 303:1180-7.

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Schlesselman JJ (2015).
Jerome Cornfield’s Bayesian approach to assessing interim results in clinical trials. JLL Bulletin: Commentaries on the history of treatment evaluation.

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Zwarenstein M (2016).
‘Pragmatic’ and ‘Explanatory’ attitudes to randomized trials. JLL Bulletin: Commentaries on the history of treatment evaluation.

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