Crossover tests

Random allocation for treatment comparisons can be used to compare different treatments given at different times in random order to the same patient.


JLL Essay
2.2 The need to compare like-with-like in treatment comparisons

Comparing like with like

 

FILTER CLEAR FILTERS

SORT date author


FILTER RECORDS BY


Stockwell MS, CaCamargo S, Ramakrishnan R, Holleran S, Findley SE, Kukafka R, Hofstetter AM, Fernandez N, Vawdrey DK (2015)
Registry-linked electronic influenza vaccine provider reminders: a cluster-crossover trial. Pediatrics. 135:e75-82.

View

Connolly SJ, Philippon F, Longtin Y, Casanova A, Birnie DH, Exner DV, Dorian P, Prakash R, Alings M, Krahn AD (2013)
Randomized cluster crossover trials for reliable, efficient, comparative effectiveness testing: design of the Prevention of Arrhythmia Device Infection Trial (PADIT). Can J Cardiol 29:652-8.

View

Mahon JL, Laupacis A, Hodder RV, McKim DA, Paterson NA, Wood TE, Donner A (1999)
Theophylline for irreversible chronic airflow limitation: a randomized study comparing n of 1 trials to standard practice. Chest 115:38-48. PMID: 9925061

View

Guyatt GH, Keller JL, Jaeschke R, Rosenbloom D, Adachi JD, Newhouse MT (1990)
The n-of-1 randomized controlled trial: clinical usefulness. Our three-year experience. Annals of Internal Medicine 112:293-299.

View

Roifman CM, Levison H, Gelfand EW (1987)
High-dose versus low-dose intravenous immunoglobulin in hypogammaglobulinaemia and chronic lung disease. Lancet 329: 1075–1077.

View

Schinke SP, Gilchrist LD, Schilling RF, Senechal VA (1986)
Smoking and smokeless tobacco use among adolescents: trends and intervention results. Public Health Reports 101:373-8.

View

Straus B, Eisenberg J, Gennis J (1955)
Hypnotic effects of an anti-histamine – methapyrilene hydrochloride. Annals of Internal Medicine 42:574-582.

View

Hare EH (1955)
Comparative efficacy of hypnotics: a self-controlled, self-recorded clinical trial in neurotic patients. British Journal of Preventive and Social Medicine 9:140-146.

View

Hogben L, Sim M (1953)
The self-controlled and self-recorded clinical trial for low grade morbidity. British Journal of Preventative and Social Medicine 7,163-179.

View

Glaser EM, Hervey GR (1951)
The prevention of seasickness with hyoscine, Benadryl and Phenergan. Lancet 2:749-753.

View

Quin CA, Mason RM, Knowelden J (1950)
Clinical assessment of rapidly acting agents in rheumatoid arthritis. BMJ 2:810-813.

View

Bignall JR, Crofton J (1949)
Antihistamine drugs in the treatment of nausea and vomiting due to streptomycin. BMJ 1:13-14.

View

Carliner PE, Radman HM, Gay LN (1949)
Treatment of nausea and vomiting of pregnancy with Dramamine – preliminary report. Science 110:215-216.

View

Makinson DH, Oleesky S, Stone RV (1948)
Vitamin E in angina pectoris. Lancet 1:102.

View

Sigler LH, Tulgan J (1943)
Treatment of angina pectoris by testosterone propionate. New York State Journal of Medicine 43:1424-1428.

View

Harper AA, MacKay IFS, Raper HS, Camm GL (1943)
Vitamins and physical fitness. BMJ 1:243–245.

View

Dub LA, Lurie LA (1939)
Use of benzedrine in the depressed phase of the psychotic state. Ohio State Medical Journal 35:39-45.

View

Master AM, Jaffe HL, Dack S (1939)
The drug treatment of angina pectoris due to coronary artery disease. American Journal of Medical Science 197:774-782.

View

Bahnsen P, Jacobsen E, Thesleff H (1938)
Studien über die Wirkung von beta-phenyl-isopropylaminsulfdat (Mecodrin) auf normale Menschen. [Studies on the effect of beta-phenyl-isopropylaminsulfdat (Mecodrin) on normal volunteers]. Klinische Wochenschrift 17:1074-1078.

View

Gold H, Kwit NT, Otto H (1937)
The xanthines (theobromine and aminophyllin) in the treatment of cardiac pain. JAMA 108;2173-2179.

View

Bray GW, Witts LJ (1934)
Pseudo-ephedrine in asthma. Lancet 1:788-90.

View

Evans W, Hoyle C (1934)
The prevention and treatment of individual attacks of angina pectoris (angina of effort). Quarterly Journal of Medicine 3:105-135.

View

Evans W, Hoyle C (1933)
The comparative value of drugs used in the continuous treatment of angina pectoris. Quarterly Journal of Medicine 7:311-338.

View

Martini P (1932)
Methodenlehre der Therapeutischen Untersuchung [Methodological principles for therapeutic investigations]. Berlin: Springer.

View

Harris KE (1927)
Series of cases of auricular fibrillation treated with quinidine sulphate. Heart 14:283-288.

View

Jansen H (1910)
Behandling med Radiumemanation særlig ved gigtiske Lidelser [Treatment with radium emanation especially with rheumatic diseases]. Ugeskrift for Læger 72:1333-48.

View

Rivers WHR (1908)
The influence of alcohol and other drugs on fatigue. London: Edward Arnold.

View

Cushny AR, Peebles AR (1905)
The action of optical isomers. II. Hyoscines. J Physiology 32:501-510.

View

Thompson T (1859)
Observations on the administration of ozonized oils. Medical and Chirurgical Transactions 42:349-360.

View

Haygarth J (1800)
Of the imagination, as a cause and as a cure of disorders of the body: exemplified by fictitious tractors, and epidemical convulsions. Bath: R. Crutwell.

View

Parry CH (1786)
Experiments relative to the medical effects of Turkey Rhubarb, and of the English Rhubarbs, No. I and No. II made on patients of the Pauper Charity. Letters and Papers of the Bath Society 11:431-453.

View

Wiseman R (1676)
Eight chirugical treatises. London: R Royston, p 123.

View
JLL Book of EssaysHave you read the James Lind Library's Introduction to Fair Tests of Treatments?

We have edited, updated and abridged all of the Essays from the Library for 2019, and lavishly illustrated them with examples from the history of fair tests of treatments.  Share and enjoy!

Download the PDF