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James Lind Library
Illustrating the development of fair tests of treatments in health care
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ADDITIONAL METHODS - ASSESSING UNANTICIPATED EFFECTS/ADVERSE EFFECTS
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Venning GR (1982)
Validity of anecdotal reports of suspected adverse drug reactions: the problem of false alarms. BMJ 284:249-254.
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Robert E, Guibaud P (1982)
Maternal valproic acid and congenital neural tube defects. Lancet 2:937.
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Jick H, Vessey M (1978)
Case-control studies in the evaluation of drug-induced illness. American Journal of Epidemiology 1978;107:1-7.
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Jick H (1977)
The discovery of drug-induced illness. New England Journal of Medicine 296:481-485.
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Colombo F, Shapiro S, Slone D, Tognoni G (1977)
Epidemiological evaluation of drugs. Amsterdam: Elsevier/North-Holland Biomedical Press.
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Boston Collaborative Drug Surveillance Group (1974)
Regular aspirin intake and acute myocardial infarction. BMJ 1:440-443.
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Finney DJ (1965)
The design and logic of a monitor of drug use. Journal of Chronic Diseases 18:77-98.
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McBride WG (1961)
Thalidomide and congenital abnormalities. Lancet 2:1358.
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Kocher T (1883)
Ueber Kropfexstirpation und ihre Folgen [On goitre removal, and its consequences]. Archiv für Klinische Chirurgie 29:254-337.
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Reverdin J-L, Reverdin A (1883)
Note sur vingt-deux opérations de goitre, avec 3 pl. photographiques [Note on twenty two operations on goitre. Continuation and conclusion]. Revue Médicale de la Suisse Romande 3:169-198, 233-278, 309-364.
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methods
Principles of testing
Pre-clinical
Dramatic effects
N-of-1 crossover
Crossover tests
Cluster allocation
Factorial design
Double dummy
Placebo effects