People who believe that a treatment will help to relieve their symptoms may well experience improvements in their condition – even though the treatment, in fact, has no active ingredient.


 

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Papin D (1704)
123. Papin an Leibniz. In: Gerland E (1881) Leibnizens und Huygens’ Briefwechsel mit Papin. Berlin:Verlag der Koniglichen Akademie der Wissenschaften. pp 328-330.

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Marson Smith P, Colquhoun D, Chalmers I (2019).
John Henry Gaddum’s 1940 guidance on controlled clinical trials JLL Bulletin: Commentaries on the history of treatment evaluation.

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