HEALTH PROBLEMS — SYMPTOMS

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Lavoisier A-L de (1784)
Undated documents contained in: Mémoires de Lavoisier, Oeuvres, Tome III. Paris: Imprimerie Impériale, 1865. p 509.

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Gordon A (1788)
The practice of physick. Unpublished manuscript.

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Borovsky MP, Steigmann F (1933)
Amidopyrine in the treatment of measles. JAMA 100:1859-61.

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King D (1933)
Postoperative pulmonary complications. II. Carbon dioxide as a preventive in controlled series. JAMA 100: 21-6.

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Hediger E, Gold H (1935)
USP ether from large drums and ether from can labeled ‘For Anesthesia’. JAMA 104:2244-2448.

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Lennox WG, Von Storch TJC (1935)
Experiences with ergotamine tartrate in 120 patients with migraine. JAMA 105:169-171.

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Curphey TJ, Solomon S (1936)
The therapeutic value of calcium salts in serum sickness. New England Journal of Medicine 214:150-153.

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Moir JC (1936)
Clinical experiences with the new alkaloid, ergometrine. BMJ 2:799-801.

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O’Sullivan ME (1936)
Termination of 1000 attacks of migraine with ergotamine tartrate. JAMA 107:1208-1212.

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Bahnsen P, Jacobsen E, Thesleff H (1938)
Studien über die Wirkung von beta-phenyl-isopropylaminsulfdat (Mecodrin) auf normale Menschen. [Studies on the effect of beta-phenyl-isopropylaminsulfdat (Mecodrin) on normal volunteers]. Klinische Wochenschrift 17:1074-1078.

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Pratt JG, Rhine JB, Smith BM, Stuart CE, Greenwood JA (1940)
Extra-sensory perception after sixty years: a critical appraisal of the research in extra-sensory perception. New York: Henry Holt.

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French JO, Hooker ML, Vause RB, Robinson AL (1940)
Dental anaesthesia in children: a comparision of vinyl ether and ethyl chloride in a series of 200 cases. BMJ 2:432-435.

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British Homoeopathic Society (1943)
Report on mustard gas experiments (Glasgow and London). British Homoeopathic Journal 33:1-12.

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Harper AA, MacKay IFS, Raper HS, Camm GL (1943)
Vitamins and physical fitness. BMJ 1:243–245.

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Fowke H (1943)
The effect of supplements of vitamins and minerals on the health of girls. BMJ 2:519.

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Holling HE, McArdle B, Trotter WR (1944)
Prevention of seasickness by drugs. Lancet 243:127-129.

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Hill IGW, Guest AI (1945)
Prevention of sea-sickness in assault craft. BMJ 2:6–11.

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Gunther M (1945)
Sore nipples - causes and prevention. Lancet 2:590-593.

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Bransby ER, Burn JL, Magee HE, MacKecknie DM (1946)
Effect of a daily vitamin supplement on the health and development of children. BMJ 1:193-197.

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Colebrook D (1946)
Artificial sunlight treatment in industry. MRC Industrial Health Research Board Report No. 89. London: His Majesty’s Stationery Office.

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Jellinek EM (1946)
Clinical tests on comparative effectiveness of analgesic drugs. Biometric Bulletin 2:87-91.

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Magee HE (1946)
Application of nutrition to public health: some lessons of the War. BMJ 1:475-482.

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Waller H (1946)
The early failure of breast feeding: a clinical study of its causes and their prevention. Archives of Disease in Childhood 21:1-12.

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Robinson M (1947)
Cramps in pregnancy. Journal of Obstetrics and Gynaecology of the British Commonwealth 54:826-829.

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Robinson M (1947)
Hormonal treatment of deficient lactation. Lancet 2:90-92.

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Thomas DV (1948)
Benzedrine, coramine and picrotoxin: a comparison. Anaesthesia 3:122-123.

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Sølling P (1948)
Lucamid – et nyt analgeticum. [Lycamid - a new analgesic] Ugeskrift for Læger 110:1473-5.

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Asher R (1948)
A method of testing analgesics. Lancet 2:771-3.

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MRC Vitamin C subcommittee (1948)
Vitamin-C requirement of human adults. Experimental study of Vitamin-C deprivation in man. Lancet 251: 852-858.

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Bignall JR, Crofton J (1949)
Antihistamine drugs in the treatment of nausea and vomiting due to streptomycin. BMJ 1:13-14.

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Carliner PE, Radman HM, Gay LN (1949)
Treatment of nausea and vomiting of pregnancy with Dramamine – preliminary report. Science 110:215-216.

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Loveless MH (1950)
Milk allergy: a survey of its incidence; experiments with a masked ingestion test. J Allergy 21:489-499.

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Medical Research Council (1950)
Clinical trials of antihistaminic drugs in the prevention and treatment of the common cold. BMJ 2:425-431.

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Birk G, Böhm A (1950)
Leberextrakt als Roborans [Is liver extract a ‘tonic’]? Die Medizinische Welt 1:51-52.

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Cartwright EW (1951)
Dramamine in nausea and vomiting of pregnancy. Western Journal of Surgery 59: 216-234.

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Glaser EM, Hervey GR (1951)
The prevention of seasickness with hyoscine, Benadryl and Phenergan. Lancet 2:749-753.

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Neuwirth I, Chilton NW (1951)
The clinical effectiveness of different concentrations of procaine for mandibular extractions. Oral Surgery, Oral Medicine and Oral Pathology 4:383-387.

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Hogben L, Sim M (1953)
The self-controlled and self-recorded clinical trial for low grade morbidity. British Journal of Preventative and Social Medicine 7,163-179.

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Hare EH (1955)
Comparative efficacy of hypnotics: a self-controlled, self-recorded clinical trial in neurotic patients. British Journal of Preventive and Social Medicine 9:140-146.

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Straus B, Eisenberg J, Gennis J (1955)
Hypnotic effects of an anti-histamine – methapyrilene hydrochloride. Annals of Internal Medicine 42:574-582.

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Newton DRL, Tanner JM (1956)
N-acetyl-para-aminophenol as an analgesic. A controlled clinical trial using the method of sequential analysis. BMJ 2:1096-9.

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Snell ES, Armitage P (1957)
Clinical comparison of diamorphine and pholcodine as cough suppressants by a new method of sequential analysis. Lancet 1:860-862

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McBride WG (1961)
Thalidomide and congenital abnormalities. Lancet 2:1358.

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Assaf RA, Dundee JW, Gamble JA (1975)
The influence of the route of administration on the clinical action of diazepam. Anesthesia 30:152-8.

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Harding SM, Heath S (1976)
Intranasal steroid aerosol in perennial rhinitis: comparison with an antihistamine compound. Journal of Clinical Allergy 6:369-72.

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Beaver WT, Feise GA (1977)
A comparison of the analgesic effect of oxymorphone by rectal suppository and intramuscular injection in patients with postoperative pain. Journal of Clinical Pharmacology 17:276-91.

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Jick H (1977)
The discovery of drug-induced illness. New England Journal of Medicine 296:481-485.

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Rhind VM, Leatham PA, Wright V, Akbar FA, Downie WW (1978)
A comparative study of floctafenine (Idarac) and ibuprofen in the treatment of osteoarthrosis. Journal of International Medicial Research 2:11-13.

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Jick H, Vessey M (1978)
Case-control studies in the evaluation of drug-induced illness. American Journal of Epidemiology 1978;107:1-7.

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Farquhar JW (1978)
The community-based model of life style intervention trials. American Journal of Epidemiology 108:103-111.

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Donald JF, Molla AL (1978)
A controlled study comparing a three times daily dose of chlordiazepoxide with a single night-time dose of Trancopal in the control of anxiety, using a double-blind, double-dummy technique. J Int Med Res 6:105-10.

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Mirakhur RK, Dundee JW, Connolly JD (1979)
Studies of drugs given before anaesthesia. XVII: anticholinergic premedicants. British Journal of Anesthesia 51:339-45.

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Mazzuca SA (1982)
Does patient education in chronic disease have therapeutic value? Journal of Chronic Diseases 35:521-529.

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Venning GR (1982)
Validity of anecdotal reports of suspected adverse drug reactions: the problem of false alarms. BMJ 284:249-254.

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Dwyer T, Coonan WE, Leitch DR, Hetzel BS, Baghurst RA (1983)
An investigation of the effects of daily physical activity on the health of primary school students in South Australia. International Journal of Epidemiology 12:308-13.

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Rubenstein LV, Calkins DR, Young RT, Cleary PD, Fink A, Kosecoff J, Jette AM, Davies AR, Delbanco TL, Brook RH (1989)
Improving patient function: A randomized trial of functional disability screening. Annals of Internal Medicine 111:836-842.

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Abdeljaber MH, Monto AS, Tilden RL, Schork MA, Tarwotjo I (1991)
The impact of Vitamin A supplementation on morbidity: a randomized community intervention trial. American Journal of Public Health 81:1654-1656.

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Sutton CJ, Ewen SP, Whitelaw N, Haines P (1994)
Prospective, randomized, double-blind, controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal, mild, and moderate endometriosis. Fertil Steril 62:696–700.

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Pound P, Nicol CJ (2018)
Retrospective harm benefit analysis of pre-clinical animal research for six treatment interventions. . PLoS ONE 13(3): e0193758. https://doi.org/10.1371/journal. pone.0193758.

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Horby P, Lim WS, Emberson J, Mafham M, Bell J, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B, Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffrey K, Montgomery A, Rowan K, Juszcak E, Baillie JK, Haynes R, Landray MJ, on behalf of the RECOVERY Collaborative Group (2020)
Effect of Dexamethasone in Hospitalized Patients with COVID-19: Preliminary Report. medRχiv. Doi: https://doi.org/10.1101/2020.06.22.20137273

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Horby P, Mafham M, Linsell L, Bell JL, Staplin N, Emberson JR, Wiselka M, Ustianowski A, Elmahi E, Prudon B, Whitehouse A, Felton T, Williams J, Faccenda J, Underwood J, Baillie JK, Chappell L, Faust SN, Jaki T, Jeffery K, Lim WS, Montgomery A, Rowan K, Tarning J, Watson JA, White NJ, Juszczak E, Haynes R, Landray MJ (2020)
Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial. doi: https://doi.org/10.1101/2020.07.15.20151852

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RECOVERY Trial Team (2020)
Randomized Evaluation of COVID019 Therapy (RECOVERY). RECOVERY Central Coordinating Office, Oxford. www.recoverytrial.net

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Pan H, Peto R, Karim QA, Alejandria M, Henao-Restrepo AM, García CH, Kieny MP, Malekzadeh R, Murthy S, Preziosi MP, Reddy S, Periago MR, Sathiyamoorthy V, Røttingen JA, Swaminathan S, WHO Solidarity trial consortium (2020)
Repurposed antiviral drugs for COVID-19 –interim WHO SOLIDARITY trial results. MedRxiv. doi: https://doi.org/10.1101/2020.10.15.20209817

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Rolls R (2003).
Caleb Hillier Parry (1755-1822). JLL Bulletin: Commentaries on the history of treatment evaluation.

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Gong Y, Gluud C (2003).
Commentary on the Ben Cao Tu Jing (11th century). Atlas of Materia Medica. Song Dynasty (960-1279). JLL Bulletin: Commentaries on the history of treatment evaluation.

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Donaldson IML (2005).
Mesmer’s 1780 proposal for a controlled trial to test his method of treatment using ‘Animal Magnetism’. JLL Bulletin: Commentaries on the history of treatment evaluation.

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Agnew RAL (2008).
John Forbes FRS (1787-1861). JLL Bulletin: Commentaries on the history of treatment evaluation.

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Edwards M (2010).
Dora Colebrook and the evaluation of light therapy. JLL Bulletin: Commentaries on the history of treatment evaluation.

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Donaldson IML (2016).
Antoine de Lavoisier’s role in designing a single-blind trial to assess whether ‘Animal Magnetism’ exists. JLL Bulletin: Commentaries on the history of treatment evaluation.

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Mirza RD, Punja S, Vohra S, Guyatt G (2017).
The history and development of N of 1 trials. JLL Bulletin: Commentaries on the history of treatment evaluation.

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Senn SJ (2017).
Cushny and Peebles, optical isomers, and the birth of modern statistics. JLL Bulletin: Commentaries on the history of treatment evaluation.

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La Rochelle P (2017).
Using randomized, double-blind, n-of-1 trials of food challenge to diagnose food allergy and assess the effectiveness of food allergen avoidance. JLL Bulletin: Commentaries on the history of treatment evaluation.

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Tröhler U (2020)
Probabilistic thinking and the evaluation of therapies, 1700-1900. JLL Bulletin: Commentaries on the history of treatment evaluation.

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