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Illustrating the development of fair tests of treatments in health care
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ADDITIONAL METHODS - NATURAL COURSE OF ILLNESS
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Petrarca F (14th century)
Letter to Boccaccio. Print: Senilium Liber V Epistola iii in: Annotatio nonnullorum librorum seu epistolarum Francisci Petrarche. Venetiis: Torresanus de Asula (1501). Manuscript: Key passage in the late 14th / early 15th century manuscript Biblioteca Marciana Lat. XI 17 / Francesco Petrarca; fol. 28r, second column, lines 9 – 22. (Facsimile of MS: Petrarca F (2003). Seniles, (eds Stocchi MP, Marcon S). Venice: Marsilio.)
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Stuart, James, King of Great Britaine, France and Ireland (1616)
A counterblaste to tobacco. In: The workes of the most high and mightie prince, James Published by James, Bishop of Winton, and Deane of his Majesties Chappel Royall. London: printed by Robert Barker and John Bill, printers to the Kings most excellent Majestie, pp 214-222.
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Gregory J (1772)
Lectures on the duties and qualifications of a physician. London: Strahan and Cadell. (new ed.) Edinburgh: Creech.
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Bigelow J (1835)
A discourse on self-limited diseases, delivered before the Massachusetts Medical Society at their annual meeting, May 27, 1835. Boston: Nathan Hale p 8-10.
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Holmes OW (1861)
Currents and countercurrents in medical science with other addresses and essays. Boston: Ticknor and Fields, 1861.
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Bennett JH (1865)
The restorative treatment of pneumonia. Edinburgh, AC Black.
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methods
Principles of testing
Pre-clinical
Dramatic effects
N-of-1 crossover
Crossover tests
Cluster allocation
Factorial design
Double dummy
Placebo effects