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James Lind Library
Illustrating the development of fair tests of treatments in health care
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ADDITIONAL METHODS - BENEFITS/HARMS
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Watson W (1768)
An account of a series of experiments, instituted with a view of ascertaining the most successful method of inoculating the smallpox. London: J Nourse.
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Gregory J (1772)
Lectures on the duties and qualifications of a physician. London: Strahan and Cadell. (new ed.) Edinburgh: Creech.
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Fordyce G (1802)
A second dissertation on fever. London: J Johnson.
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Currie W (1804)
Medical reports of the effects of water: cold and warm as a remedy in fever and febrile diseases. Vol. 2. London: M’Creery & Cadell.
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O’Dwyer J (1887)
Fifty cases of croup in private practice treated by intubation of the larynx, with a description of the method and of the dangers incident thereto. Medical Record 32:557-561.
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Behring EA, Boer NN, Kossel H (1893)
Zur Behandlung diphtheriekranker Menschen mit Diphtherieheilserum [On the treatment of diphtheria patients with curative diphtheria serum]. Deutsche Medicinische Wochenschrift 17:389-39.
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Lanman TH, Heyl HL (1939)
Empyema in Children. New England Journal of Medicine 221:1003-1009.
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methods
Principles of testing
Pre-clinical
Dramatic effects
N-of-1 crossover
Crossover tests
Cluster allocation
Factorial design
Double dummy
Placebo effects