Double dummy

In a double dummy trial, there are usually two placebos.


JLL Essay
The need to avoid differences in the way outcomes are assessed

Fair tests of treatments

 

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Dudley Hart F, Boardman PL (1965)
Indomethacin and phenylbutazone: a comparison. BMJ 2:1281-1284.

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Wright V, Walker WC, McGuire RJ (1969)
Indomethacin in the treatment of rheumatoid arthritis. Annals of Rheumatic Diseases 28:157-162.

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Dürrigl T, Vitaus, Pucar I, Miko M (1975)
Diclofenac sodium (Voltaren): results of a multicentre comparative trial in adult-onset rheumatoid arthritis. Journal of International Medical Research 3:139-44.

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Assaf RA, Dundee JW, Gamble JA (1975)
The influence of the route of administration on the clinical action of diazepam. Anesthesia 30:152-8.

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Harding SM, Heath S (1976)
Intranasal steroid aerosol in perennial rhinitis: comparison with an antihistamine compound. Journal of Clinical Allergy 6:369-72.

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Murphy JE (1977)
A comparative trial of Anafranil, Pertofran and an Anafranil/Pertofran combination. Journal of International Medical Research 5(1 Suppl):16-23.

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Beaver WT, Feise GA (1977)
A comparison of the analgesic effect of oxymorphone by rectal suppository and intramuscular injection in patients with postoperative pain. Journal of Clinical Pharmacology 17:276-91.

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Gam F, Helles A, Andersen B (1977)
Hormonal treatment of climacteric complaints. A controlled, double-blind comparative study between 2 different types of sequential estrogen-gestagen preparations [in Danish]. Ugeskr Laeger 139:2808-12.

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Wettrell K (1977)
Intraocular pressure reduction during treatment with pilocarpine and systemic propranolol. A comparative double-masked study. Albrecht Von Graefes Arch Klin Exp Ophthalmol 204:1-7.

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Donald JF, Molla AL (1978)
A controlled study comparing a three times daily dose of chlordiazepoxide with a single night-time dose of Trancopal in the control of anxiety, using a double-blind, double-dummy technique. J Int Med Res 6:105-10.

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Rhind VM, Leatham PA, Wright V, Akbar FA, Downie WW (1978)
A comparative study of floctafenine (Idarac) and ibuprofen in the treatment of osteoarthrosis. Journal of International Medicial Research 2:11-13.

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Blohmé G, Waldenström J (1979)
Glibenclamide and glipizide in maturity onset diabetes. A double-blind cross-over study. Acta Medica Scandinavica 206:263-7.

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Mirakhur RK, Dundee JW, Connolly JD (1979)
Studies of drugs given before anaesthesia. XVII: anticholinergic premedicants. British Journal of Anesthesia 51:339-45.

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Davidson I, Hillier VF (2002)
Comparison of four methods of allocation for clinical trials with small sample sizes. Physiotherapy 88;12:722-729, ISSN 0031-9406.

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D'Aquila RT, Hughes MD, Johnson VA, Fischl MA, Sommadossi JP, Liou SH, Timpone J, Myers M, Basgoz N, Niu M, Hirsch MS (2021)
Nevirapine, zidovudine, and didanosine compared with zidovudine and didanosine in patients with HIV-1 infection. A randomized, double- blind, placebo-controlled trial. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group Protocol 241 Investigators. Annals of Internal Medicine 124:1019-1030.

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Senn SJ, Chalmers I (2021).
Giving and taking: ethical treatment assignment in controlled trials. JLL Bulletin: Commentaries on the history of treatment evaluation.

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Glasziou P, Matthews R, Boutron I, Chalmers I, Armitage P† (2023)
The differences and overlaps between ‘explanatory’ and ‘pragmatic’ controlled trials: a historical perspective. JLL Bulletin: Commentaries on the history of treatment evaluation.

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