Design bias

The design of treatment research often reflects commercial and academic interests; ignores relevant existing evidence; uses comparison treatments known in advance to be inferior; and ignores needs of users of research results (patients, health professionals and others).


 

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Misemer BS, Platts-Mills TF, Jones CW (2016)
Citation bias favoring positive clinical trials of thrombolytics for acute ischemic stroke: a cross-sectional analysis. Trials 17:473.

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Page MJ, Higgins JPT, Clayton G, Sterne JAC, Hróbjartsson A, Savović J (2016)
Empirical Evidence of Study Design Biases in Randomized Trials: Systematic Review of Meta-Epidemiological Studies. PLOS ONE 11(7):e0159267.

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Campbell DT, Stanley JC (1963)
Experimental and quasi-experimental designs for research. Chicago: Rand McNally & Company.

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Mainland D (1963)
Elementary medical statistics: 2nd edn. Philadelphia: WB Saunders Co.

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McCall WA (1923)
How to experiment in education. New York: Macmillan.

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Mann H, Djulbegovic B (2012).
Comparator bias: why comparisons must address genuine uncertainties. JLL Bulletin: Commentaries on the history of treatment evaluation.

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