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James Lind Library
Illustrating the development of fair tests of treatments in health care
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ADDITIONAL METHODS - CROSSOVER TESTS
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Wiseman R (1676)
Eight chirugical treatises. London: R Royston, p 123.
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Parry CH (1786)
Experiments relative to the medical effects of Turkey Rhubarb, and of the English Rhubarbs, No. I and No. II made on patients of the Pauper Charity. Letters and Papers of the Bath Society 11:431-453.
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Haygarth J (1800)
Of the imagination, as a cause and as a cure of disorders of the body: exemplified by fictitious tractors, and epidemical convulsions. Bath: R. Crutwell.
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Thompson T (1859)
Observations on the administration of ozonized oils. Medical and Chirurgical Transactions 42:349-360.
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Cushny AR, Peebles AR (1905)
The action of optical isomers. II. Hyoscines. J Physiology 32:501-510.
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Rivers WHR (1908)
The influence of alcohol and other drugs on fatigue. London: Edward Arnold.
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Jansen H (1910)
Behandling med Radiumemanation særlig ved gigtiske Lidelser [Treatment with radium emanation especially with rheumatic diseases]. Ugeskrift for Læger 72:1333-48.
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Harris KE (1927)
Series of cases of auricular fibrillation treated with quinidine sulphate. Heart 14:283-288.
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Martini P (1932)
Methodenlehre der Therapeutischen Untersuchung [Methodological principles for therapeutic investigations]. Berlin: Springer.
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Evans W, Hoyle C (1933)
The comparative value of drugs used in the continuous treatment of angina pectoris. Quarterly Journal of Medicine 7:311-338.
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Evans W, Hoyle C (1934)
The prevention and treatment of individual attacks of angina pectoris (angina of effort). Quarterly Journal of Medicine 3:105-135.
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Bray GW, Witts LJ (1934)
Pseudo-ephedrine in asthma. Lancet 1:788-90.
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Gold H, Kwit NT, Otto H (1937)
The xanthines (theobromine and aminophyllin) in the treatment of cardiac pain. JAMA 108;2173-2179.
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Bahnsen P, Jacobsen E, Thesleff H (1938)
Studien über die Wirkung von beta-phenyl-isopropylaminsulfdat (Mecodrin) auf normale Menschen. [Studies on the effect of beta-phenyl-isopropylaminsulfdat (Mecodrin) on normal volunteers]. Klinische Wochenschrift 17:1074-1078.
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Master AM, Jaffe HL, Dack S (1939)
The drug treatment of angina pectoris due to coronary artery disease. American Journal of Medical Science 197:774-782.
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Dub LA, Lurie LA (1939)
Use of benzedrine in the depressed phase of the psychotic state. Ohio State Medical Journal 35:39-45.
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Harper AA, MacKay IFS, Raper HS, Camm GL (1943)
Vitamins and physical fitness. BMJ 1:243–245.
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Sigler LH, Tulgan J (1943)
Treatment of angina pectoris by testosterone propionate. New York State Journal of Medicine 43:1424-1428.
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Makinson DH, Oleesky S, Stone RV (1948)
Vitamin E in angina pectoris. Lancet 1:102.
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Carliner PE, Radman HM, Gay LN (1949)
Treatment of nausea and vomiting of pregnancy with Dramamine – preliminary report. Science 110:215-216.
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Bignall JR, Crofton J (1949)
Antihistamine drugs in the treatment of nausea and vomiting due to streptomycin. BMJ 1:13-14.
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Quin CA, Mason RM, Knowelden J (1950)
Clinical assessment of rapidly acting agents in rheumatoid arthritis. BMJ 2:810-813.
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Glaser EM, Hervey GR (1951)
The prevention of seasickness with hyoscine, Benadryl and Phenergan. Lancet 2:749-753.
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Hogben L, Sim M (1953)
The self-controlled and self-recorded clinical trial for low grade morbidity. British Journal of Preventative and Social Medicine 7,163-179.
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Hare EH (1955)
Comparative efficacy of hypnotics: a self-controlled, self-recorded clinical trial in neurotic patients. British Journal of Preventive and Social Medicine 9:140-146.
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Straus B, Eisenberg J, Gennis J (1955)
Hypnotic effects of an anti-histamine – methapyrilene hydrochloride. Annals of Internal Medicine 42:574-582.
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Schinke SP, Gilchrist LD, Schilling RF, Senechal VA (1986)
Smoking and smokeless tobacco use among adolescents: trends and intervention results. Public Health Reports 101:373-8.
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Roifman CM, Levison H, Gelfand EW (1987)
High-dose versus low-dose intravenous immunoglobulin in hypogammaglobulinaemia and chronic lung disease. Lancet 329: 1075–1077.
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Guyatt GH, Keller JL, Jaeschke R, Rosenbloom D, Adachi JD, Newhouse MT (1990)
The n-of-1 randomized controlled trial: clinical usefulness. Our three-year experience. Annals of Internal Medicine 112:293-299.
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Mahon JL, Laupacis A, Hodder RV, McKim DA, Paterson NA, Wood TE, Donner A (1999)
Theophylline for irreversible chronic airflow limitation: a randomized study comparing n of 1 trials to standard practice. Chest 115:38-48. PMID: 9925061
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Connolly SJ, Philippon F, Longtin Y, Casanova A, Birnie DH, Exner DV, Dorian P, Prakash R, Alings M, Krahn AD (2013)
Randomized cluster crossover trials for reliable, efficient, comparative effectiveness testing: design of the Prevention of Arrhythmia Device Infection Trial (PADIT). Can J Cardiol 29:652-8.
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Stockwell MS, CaCamargo S, Ramakrishnan R, Holleran S, Findley SE, Kukafka R, Hofstetter AM, Fernandez N, Vawdrey DK (2015)
Registry-linked electronic influenza vaccine provider reminders: a cluster-crossover trial. Pediatrics. 135:e75-82.
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methods
Principles of testing
Pre-clinical
Dramatic effects
N-of-1 crossover
Crossover tests
Cluster allocation
Factorial design
Double dummy
Placebo effects